Document Detail


Iron deficiency and brain development.
MedLine Citation:
PMID:  17101454     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Iron deficiency (ID) is common in pregnant women and infants worldwide. Rodent models show that ID during gestation/lactation alters neurometabolism, neurotransmitters, myelination, and gene/protein profiles before and after iron repletion at weaning. Human infants with iron deficiency anemia test lower in cognitive, motor, social-emotional, and neurophysiologic development than comparison group infants. Iron therapy does not consistently improve developmental outcome, with long-term differences observed. Poorer outcome has also been shown in human and monkey infants with fetal/neonatal ID. Recent randomized trials of infant iron supplementation show benefits, indicating that adverse effects can be prevented and/or reversed with iron earlier in development or before ID becomes severe or chronic. This body of research emphasizes the importance of protecting the developing brain from ID.
Authors:
Betsy Lozoff; Michael K Georgieff
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review    
Journal Detail:
Title:  Seminars in pediatric neurology     Volume:  13     ISSN:  1071-9091     ISO Abbreviation:  Semin Pediatr Neurol     Publication Date:  2006 Sep 
Date Detail:
Created Date:  2006-11-14     Completed Date:  2007-01-17     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  9441351     Medline TA:  Semin Pediatr Neurol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  158-65     Citation Subset:  IM    
Affiliation:
Center for Human Growth and Development, Department of Pediatrics and Communicable Diseases, University of Michigan, Ann Arbor, MI 48109-0406, USA. blozoff@umich.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Brain / embryology,  growth & development*
Child, Preschool
Female
Fetus / physiology
Humans
Infant
Infant, Newborn
Iron / deficiency*
Mice
Pregnancy
Rats
Grant Support
ID/Acronym/Agency:
P01 HD039386-01A1/HD/NICHD NIH HHS; P01 HD039386-01A10001/HD/NICHD NIH HHS; P01 HD039386-02/HD/NICHD NIH HHS; P01 HD039386-020001/HD/NICHD NIH HHS; P01 HD039386-03/HD/NICHD NIH HHS; P01 HD039386-04/HD/NICHD NIH HHS; P01 HD039386-05/HD/NICHD NIH HHS; P01 HD39386/HD/NICHD NIH HHS; R01 HD29421/HD/NICHD NIH HHS
Chemical
Reg. No./Substance:
7439-89-6/Iron

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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