| Iron-deficiency anemia, non-iron-deficiency anemia and HbA1c among adults in the US*. | |
| | |
MedLine Citation:
|
PMID: 20942846 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
Background: Conditions that affect erythrocyte turnover affect HbA1c concentrations. Although many forms of anemia are associated with lowering of HbA1c, iron deficiency tends to increase HbA1c. We examined the effect of iron and hemoglobin (Hb) status on HbA1c and on the relationship between concentrations of fasting glucose and HbA1c in a national sample of adults in the US. Methods: Cross-sectional data from 8296 adults aged ≥20 years who participated in NHANES 1999-2002 were used. Results: The prevalence of low Hb (defined as <120 and <118 g/L in women aged 20-69 and ≥70 years, respectively, and <137, <133, and <124 g/L in men aged 20-49, 50-69, and ≥70 years, respectively) was 5.5%. There was a significant positive correlation between Hb concentrations and HbA1c concentrations after adjusting for age, gender, and race or ethnicity, with HbA1c rising from a mean of 5.28% among participants with Hb <100 g/L to 5.72% among participants with Hb ≥170 g/L. The adjusted mean concentrations of HbA1c were 5.56% and 5.46% among participants with and without iron deficiency, respectively (P = 0.095). However, there was no evidence of differences in the relationship between fasting glucose and HbA1c when groups of anemic and non-anemic individuals with and without iron deficiency were examined individually. Conclusions: Caution should be used when diagnosing diabetes and prediabetes among people with high or low Hb when the HbA1c level is near 6.5% or 5.7%, respectively, as changes in erythrocyte turnover may alter the test result. However, the trend for HbA1c to increase with iron deficiency does not appear to require screening for iron deficiency in ascertaining the reliability of HbA1c in the diagnosis of diabetes and prediabetes in a given individual. |
| | |
Authors:
|
Earl S Ford; Catherine C Cowie; Chaoyang Li; Yehuda Handelsman; Zachary T Bloomgarden |
Related Documents
:
|
9240876 - High risk of helicobacter pylori infection associated with cow's milk antibodies in you... 2621526 - Milk lactose, citrate, and glucose as markers of lactogenesis in normal and diabetic wo... 690886 - The role of the autonomic nervous system in the control of pancreatic endocrine respons... 9621246 - The effect of enhanced milk yield of dairy cows by frequent milking or suckling on inta... 20816226 - The drosophila 7-pass transmembrane glycoprotein boss and metabolic regulation: what dr... 18298986 - Diabetes management in the hospital. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Journal of diabetes Volume: 3 ISSN: 1753-0407 ISO Abbreviation: J Diabetes Publication Date: 2011 Mar |
Date Detail:
|
Created Date: 2011-02-21 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101504326 Medline TA: J Diabetes Country: Australia |
Other Details:
|
Languages: eng Pagination: 67-73 Citation Subset: IM |
Copyright Information:
|
© 2011 Ruijin Hospital, Shanghai Jiaotong University School of Medicine and Blackwell Publishing Asia Pty Ltd. |
Affiliation:
|
Division of Adult and Community Health, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, Georgia National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland Metabolic Institute of America, Tarzana, California Department of Medicine, Mount Sinai School of Medicine, New York, New York, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Phosphatidylinositol 3-kinase-? up-regulates L-type Ca2+ currents and increases vascular contractili...
Next Document: Impact of sex, age, race, ethnicity and aspirin use on bleeding symptoms in healthy adults.