| Iron deficiency alters brain development and functioning. | |
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MedLine Citation:
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PMID: 12730445 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Iron deficiency anemia in early life is related to altered behavioral and neural development. Studies in human infants suggest that this is an irreversible effect that may be related to changes in chemistry of neurotransmitters, organization and morphology of neuronal networks, and neurobiology of myelination. The acquisition of iron by the brain is an age-related and brain-region-dependent process with tightly controlled rates of movement of iron across the blood-brain barrier. Dopamine receptors and transporters are altered as are behaviors related to this neurotransmitter. The growing body of evidence suggests that brain iron deficiency in early life has multiple consequences in neurochemistry and neurobiology. |
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Authors:
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John Beard |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.; Review |
Journal Detail:
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Title: The Journal of nutrition Volume: 133 ISSN: 0022-3166 ISO Abbreviation: J. Nutr. Publication Date: 2003 May |
Date Detail:
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Created Date: 2003-05-05 Completed Date: 2003-06-12 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0404243 Medline TA: J Nutr Country: United States |
Other Details:
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Languages: eng Pagination: 1468S-72S Citation Subset: IM |
Affiliation:
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Graduate Program in Nutrition, The Pennsylvania State University, University Park, PA 16802, USA. its@psu.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Age Factors Aging Animals Brain / growth & development, physiology* Dopamine / metabolism Humans Infant Iron / deficiency*, metabolism* |
| Grant Support | |
ID/Acronym/Agency:
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P01-HD39386/HD/NICHD NIH HHS; R01-NS34280/NS/NINDS NIH HHS; R01-NS35088/NS/NINDS NIH HHS |
| Chemical | |
Reg. No./Substance:
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7439-89-6/Iron |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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