| Iron acquisition in Haemophilus influenzae: receptors for human transferrin. | |
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MedLine Citation:
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PMID: 1588135 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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As an adaptation to the iron-limited environment of the host, Haemophilus influenzae has a transferrin receptor-mediated mechanism of iron acquisition such that it can acquire iron directly from human transferrin. The absence of detectable siderophore production and the presence of transferrin binding in a collection of type b and nontypeable H. influenzae strains indicate that the mechanism is widespread in this species. Growth and binding studies have consistently shown that the receptor is specific for human transferrin, which correlates with the host range of this pathogen. Inhibitor experiments indicate that iron regulation of receptor activity is mediated at the gene level. Affinity isolation experiments indicate that, as observed with other bacterial pathogens, the receptor is composed of two iron-repressible outer membrane proteins, transferrin binding proteins 1 and 2. |
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Authors:
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A B Schryvers; S Gray-Owen |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: The Journal of infectious diseases Volume: 165 Suppl 1 ISSN: 0022-1899 ISO Abbreviation: J. Infect. Dis. Publication Date: 1992 Jun |
Date Detail:
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Created Date: 1992-06-25 Completed Date: 1992-06-25 Revised Date: 2005-11-16 |
Medline Journal Info:
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Nlm Unique ID: 0413675 Medline TA: J Infect Dis Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: S103-4 Citation Subset: AIM; IM |
Affiliation:
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Department of Microbiology and Infectious Diseases, Faculty of Medicine, University of Calgary, Canada. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Bacterial Outer Membrane Proteins
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analysis Haemophilus influenzae / metabolism* Humans Iron / metabolism* Receptors, Transferrin / analysis*, metabolism |
| Chemical | |
Reg. No./Substance:
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0/Bacterial Outer Membrane Proteins; 0/Receptors, Transferrin; 7439-89-6/Iron |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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