| Iron acquisition, assimilation and regulation in mycobacteria. | |
| | |
MedLine Citation:
|
PMID: 21414421 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Iron is as crucial to the pathogen as it is to the host. The tuberculosis causing bacillus, Mycobacterium tuberculosis (M.tb), is an exceptionally efficient pathogen that has evolved proficient mechanisms to sequester iron from the host despite its thick mycolate-rich outer covering and a highly impermeable membrane of phagolysosome within which it persists inside an infected host macrophage. Further, both overindulgence and moderation of iron inside a host are a threat to mycobacterial persistence. While for removing iron from the host reservoirs, mycobacteria synthesize molecules that have several times higher affinity for iron than their host counterparts, they also synthesize molecules for efficient storage of excess iron. This is supported by tightly regulated iron dependent global gene expressions. In this review we discuss the various molecules and pathways evolved by mycobacteria for an efficient iron metabolism. We also discuss the less investigated players, like iron responsive proteins and iron responsive elements in mycobacteria, and highlight the lacunae in our current understanding of iron acquisition and utilization in mycobacteria with an ultimate aim to make iron metabolism as a possible anti-mycobacterial target. |
| | |
Authors:
|
Sharmistha Banerjee; Aisha Farhana; Nasreen Z Ehtesham; Seyed E Hasnain |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-3-14 |
Journal Detail:
|
Title: Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases Volume: - ISSN: 1567-7257 ISO Abbreviation: - Publication Date: 2011 Mar |
Date Detail:
|
Created Date: 2011-3-18 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101084138 Medline TA: Infect Genet Evol Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
Copyright © 2011. Published by Elsevier B.V. |
Affiliation:
|
Department of Biochemistry, School of Life Sciences, University of Hyderabad, Prof C. R. Rao Road, Hyderabad 500046, India. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Chromosomal and environmental determinants of morphometric variation in natural populations of the m...
Next Document: Impact of omega-3 fatty acids in Parkinson's disease.