| Iron accumulation in the basal ganglia following severe ischemic-anoxic insults in children. | |
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MedLine Citation:
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PMID: 3380958 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Increased iron deposition is described in four children following severe ischemic-anoxic insult and subsequent resuscitation. All cases demonstrated on T2-weighted magnetic resonance images areas of hypointensity in the basal ganglia, thalami, and white matter that were attributed to iron deposition. Associated areas of hyperintensity were also seen in the periventricular and subcortical white matter, and these were attributed to gliosis. In one case calcium deposition was also present within the areas of hypointensity. These findings suggest that after anoxic-ischemic damage, normal axonal transportation of brain iron can no longer occur. This may lead to increased accumulation of iron centrally at the sites of iron uptake in the basal ganglia and in the white matter. Additional iron deposition may occur more rapidly due to direct injury by lipid peroxidation degradation products catalyzed by iron. |
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Authors:
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R B Dietrich; W G Bradley |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Radiology Volume: 168 ISSN: 0033-8419 ISO Abbreviation: Radiology Publication Date: 1988 Jul |
Date Detail:
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Created Date: 1988-07-21 Completed Date: 1988-07-21 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0401260 Medline TA: Radiology Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 203-6 Citation Subset: AIM; IM |
Affiliation:
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Department of Radiological Sciences, University of California Los Angeles School of Medicine 90024. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Basal Ganglia
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metabolism*,
pathology Brain / pathology Brain Ischemia / metabolism*, pathology Child Child, Preschool Female Humans Hypoxia, Brain / metabolism*, pathology Infant, Newborn Iron / metabolism* Magnetic Resonance Imaging Male Resuscitation |
| Chemical | |
Reg. No./Substance:
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7439-89-6/Iron |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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