| Iron absorption from experimental infant formulas based on pea (Pisum sativum)-protein isolate: the effect of phytic acid and ascorbic acid. | |
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MedLine Citation:
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PMID: 11227034 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Infant formula based on pea (Pisum sativum)-protein isolate has been suggested as an alternative to soybean formula in countries where soybean is not a native crop, or when soybean protein cannot be used due to allergic reactions or intolerances. In the present study, Fe absorption from experimental infant formulas based on pea-protein isolate was measured in healthy non-anaemic young women. The influence of phytic acid and ascorbic acid on Fe absorption was evaluated, using a stable-isotope technique based on incorporation of Fe stable-isotope labels into erythrocytes 14 d after administration. Geometric mean Fe absorption increased from 20.7 (+1 SD 41.6, -1 SD 10.3) % to 33.1 (+1 SD 58.6, -1 SD 18.7) %; (P < 0.0001; n 10) after enzymic degradation of virtually all phytic acid. Doubling the molar ratio Fe:ascorbic acid from 1:2.1 to 1:4.2 in the infant formula with native phytic acid content also increased Fe absorption significantly (P < 0.0001; n 10); geometric mean Fe absorption increased from 14.8 (+1 SD 32.1, -1 SD 6.8) % to 22.1 (+1 SD 47.2, -1 SD 10.4) %. These results confirm the inhibitory and enhancing effects of phytic acid and ascorbic acid respectively on Fe absorption, but also indicate relatively high fractional Fe absorption from the pea-protein-based formulas. After adjusting for differences in Fe status, our data indicate that Fe absorption from dephytinised pea protein might be less inhibitory than dephytinised soybean protein as measured in a previous study (Hurrell et al. 1998). |
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Authors:
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L Davidsson; T Dimitriou; T Walczyk; R F Hurrell |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The British journal of nutrition Volume: 85 ISSN: 0007-1145 ISO Abbreviation: Br. J. Nutr. Publication Date: 2001 Jan |
Date Detail:
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Created Date: 2001-03-06 Completed Date: 2001-03-22 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 0372547 Medline TA: Br J Nutr Country: England |
Other Details:
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Languages: eng Pagination: 59-63 Citation Subset: IM |
Affiliation:
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Laboratory for Human Nutrition, Institute of Food Science, Swiss Federal Institute of Technology, Rüschlikon, Switzerland. davidsson@ilw.agrl.ethz.ch. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Ascorbic Acid / pharmacology Female Humans Infant Infant Food* Infant Nutritional Physiological Phenomena* Infant, Newborn Intestinal Absorption / drug effects Iron / pharmacokinetics* Peas* Phytic Acid / pharmacology Plant Proteins* |
| Chemical | |
Reg. No./Substance:
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0/Plant Proteins; 50-81-7/Ascorbic Acid; 7439-89-6/Iron; 83-86-3/Phytic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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