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Iron Status at Birth and at 4 Weeks in Preterm Small-for-Geastation (SGA) Infants in Comparison with Preterm and Term Appropriate-for-Gestation (AGA) infants.
MedLine Citation:
PMID:  22122236     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Abstract Objective: To determine the iron status at birth in preterm SGA in comparison with preterm AGA and term AGA infants Methods: Mother infant pairs with gestation of <37 weeks, both SGA and AGA and term AGA as control were enrolled. Maternal,cord blood and infant blood samples at 4 weeks were obtained for various iron indices- cord serum ferritin, proportion of infants with 'low' serum ferritin, serum ferritin at 4 weeks and correlation among maternal and neonatal iron indices- Hb,serum ferritin and total iron binding capacity (TIBC) Results: There were 50 mother-infant pairs in each group. Cord serum ferritin levels were less in preterm-SGA group as compared to preterm-AGA group [median (IQR): 68 (30,113) vs. 120 (73,127), p=0.002] and preterm AGA had less cord ferritin than term AGA {141(63,259) p=0.006}. The proportion of the infants with 'low' serum ferritin were more in preterm-SGA than in preterm-AGA [16(32%) vs. 5(10%), p=0.01]. The serum ferritin levels at follow up were also less in preterm-SGA as compared to preterm-AGA (143.5±101 vs. 235.1±160, p=0.004).. Other cord blood iron indices and follow up serum ferritin levels were similar.. There was no correlation among various maternal and neonatal cord iron parameters. Conclusions: Preterm-SGA infants have lesser total iron stores as compared to gestation matched AGA infants which is again lesser than term infants. Future studies can be planned to look at iron status at 12 months as well as their neurodevelopmental outcome.
Authors:
Kanya Mukhopadhyay; Ramesh Kumar Yadav; Sai Sunil Kishore; Gurjeevan Garewal; Vanita Jain; Anil Narang
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-11-29
Journal Detail:
Title:  The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians     Volume:  -     ISSN:  1476-4954     ISO Abbreviation:  -     Publication Date:  2011 Nov 
Date Detail:
Created Date:  2011-11-29     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101136916     Medline TA:  J Matern Fetal Neonatal Med     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Division of Neonatology, Department of Pediatrics, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
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