Document Detail


Iron and ROS control of the DownSTream mRNA decay pathway is essential for plant fitness.
MedLine Citation:
PMID:  21946558     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A new regulatory pathway involved in plant response to oxidative stress was revealed using the iron-induced Arabidopsis ferritin AtFER1 as a model. Using pharmacological and genetic approaches, the DownSTream (DST) cis-acting element in the 3'-untranslated region of the AtFER1 mRNA was shown to be involved in the degradation of this transcript, and oxidative stress triggers this destabilization. In the two previously identified trans-acting mutants (dst1 and dst2), AtFER1 mRNA stability is indeed impaired. Other iron-regulated genes containing putative DST sequences also displayed altered expression. Further physiological characterization identified this oxidative stress-induced DST-dependent degradation pathway as an essential regulatory mechanism to modulate mRNA accumulation patterns. Alteration of this control dramatically impacts plant oxidative physiology and growth. In conclusion, the DST-dependent mRNA stability control appears to be an essential mechanism that allows plants to cope with adverse environmental conditions.
Authors:
Karl Ravet; Guilhem Reyt; Nicolas Arnaud; Gabriel Krouk; El-Batoul Djouani; Jossia Boucherez; Jean-François Briat; Frédéric Gaymard
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2011-09-23
Journal Detail:
Title:  The EMBO journal     Volume:  31     ISSN:  1460-2075     ISO Abbreviation:  EMBO J.     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2012-01-04     Completed Date:  2012-04-27     Revised Date:  2013-06-27    
Medline Journal Info:
Nlm Unique ID:  8208664     Medline TA:  EMBO J     Country:  England    
Other Details:
Languages:  eng     Pagination:  175-86     Citation Subset:  IM    
Affiliation:
Biochimie et Physiologie Moléculaire des Plantes, Centre National de la Recherche Scientifique, Institut National de la Recherche Agronomique, Université Montpellier 2, Montpellier Cedex 1, France.
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MeSH Terms
Descriptor/Qualifier:
Arabidopsis / genetics*,  metabolism
Arabidopsis Proteins / genetics*,  metabolism
Ferritins / genetics,  metabolism
Gene Expression Regulation, Plant
Iron / metabolism*
Oxidative Stress
RNA Stability*
RNA, Plant / metabolism*
Reactive Oxygen Species / metabolism*
Chemical
Reg. No./Substance:
0/Arabidopsis Proteins; 0/RNA, Plant; 0/Reactive Oxygen Species; 7439-89-6/Iron; 9007-73-2/Ferritins
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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