| Iron polymaltose versus ferrous gluconate in the prevention of iron deficiency anemia of infancy. | |
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MedLine Citation:
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PMID: 20930652 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We prospectively compared the efficacy and safety of iron deficiency anemia prophylaxis with iron gluconate (IG) or iron polymaltose complex (IPC) in healthy infants attending a community pediatric center. Participants were randomly assigned to receive one of the test drugs from age 4 to 6 months to age 12 months. Parents/guardians were given extensive information on iron-rich diets and anemia prevention. Main outcome measures were blood levels of hemoglobin, hematocrit, mean corpuscular volume, red blood cell distribution width, and serum iron, ferritin, and transferrin, in addition to adverse effects. One hundred five children completed the study: 53 in the IG group and 52 in the IPC group Mean hemoglobin levels at study end were significantly higher in the IG group (12.04±0.09 g/dL vs. 11.68±0.11, P<0.014). A hemoglobin level <11 g/dL was detected in 3 infants of the IG group, and in 10 infants of the IPC group (P<0.04). Adverse effects (spitting, vomiting, diarrhea, constipation, discolored teeth) were significantly more common in the IG group (47% vs. 25%, P>0.025). In conclusion, both oral IG and IPC prevent iron deficiency anemia in infants. Iron gluconate seems to be more effective but less tolerable. |
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Authors:
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Lutfi Jaber; Shmuel Rigler; Ahmad Taya; Fadel Tebi; Mohamad Baloum; Isaac Yaniv; Mohamad Haj Yehia; Hanna Tamary |
Publication Detail:
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Type: Comparative Study; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: Journal of pediatric hematology/oncology Volume: 32 ISSN: 1536-3678 ISO Abbreviation: J. Pediatr. Hematol. Oncol. Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-10-27 Completed Date: 2010-11-16 Revised Date: 2011-10-06 |
Medline Journal Info:
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Nlm Unique ID: 9505928 Medline TA: J Pediatr Hematol Oncol Country: United States |
Other Details:
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Languages: eng Pagination: 585-8 Citation Subset: IM |
Affiliation:
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Neurology Clinic, Schneider Children's Medical Center of Israel, Petach Tikva, Israel. jabe@bezeqint.net |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Anemia, Iron-Deficiency
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metabolism,
prevention & control* Erythrocyte Indices Female Ferric Compounds / administration & dosage*, adverse effects Ferritins / blood Ferrous Compounds / administration & dosage*, adverse effects Hematinics / administration & dosage*, adverse effects Hematocrit Hemoglobins / metabolism Humans Infant Infant, Newborn Iron / blood Male Prospective Studies Transferrin / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Ferric Compounds; 0/Ferrous Compounds; 0/Hematinics; 0/Hemoglobins; 11096-37-0/Transferrin; 18829-42-0/ferrous gluconate; 7439-89-6/Iron; 79173-09-4/teferrol; 9007-73-2/Ferritins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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