Document Detail


Iron deficiency: beyond anemia.
MedLine Citation:
PMID:  20814842     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Iron deficiency is the most common nutritional disorder affecting at least one third of world's population. Though anemia is common manifestation of iron deficiency, other effects of iron deficiency on various tissues, organs and systems are usually under recognized. Impaired brain development and cognitive, behavioural and psychomotor impairment are most worrisome manifestations of iron deficiency. Studies have demonstrated that some of these changes occurring during period of brain growth spurt (<2 years age) may be irreversible. Association of iron deficiency with febrile seizures, pica, breath holding spells, restless leg syndrome and thrombosis is increasingly being recognized. Impaired cell-mediated immunity and bactericidal function are generally noted in iron-deficient persons; however, the findings are inconsistent. Despite proven reversible functional immunological defects in vitro studies, a clinically important relationship between states of iron deficiency and susceptibility to infections remains controversial. Studies from malaria endemic regions have reported increased incidence of malaria in association with iron supplementation. These and some other aspects of iron deficiency are reviewed in this article.
Authors:
Dinesh Yadav; Jagdish Chandra
Publication Detail:
Type:  Journal Article; Review     Date:  2010-09-03
Journal Detail:
Title:  Indian journal of pediatrics     Volume:  78     ISSN:  0973-7693     ISO Abbreviation:  Indian J Pediatr     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2011-01-11     Completed Date:  2011-05-03     Revised Date:  2012-03-08    
Medline Journal Info:
Nlm Unique ID:  0417442     Medline TA:  Indian J Pediatr     Country:  India    
Other Details:
Languages:  eng     Pagination:  65-72     Citation Subset:  IM    
Affiliation:
Department of Pediatrics, Kalawati Saran Children's Hospital and Lady Hardinge Medical College, New Delhi, India. dineshmamc@gmail.com
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MeSH Terms
Descriptor/Qualifier:
Anemia, Iron-Deficiency
Child, Preschool
Deficiency Diseases / complications
Humans
Infant
Iron / deficiency*
Chemical
Reg. No./Substance:
7439-89-6/Iron

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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