| Iron deficiency: beyond anemia. | |
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MedLine Citation:
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PMID: 20814842 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Iron deficiency is the most common nutritional disorder affecting at least one third of world's population. Though anemia is common manifestation of iron deficiency, other effects of iron deficiency on various tissues, organs and systems are usually under recognized. Impaired brain development and cognitive, behavioural and psychomotor impairment are most worrisome manifestations of iron deficiency. Studies have demonstrated that some of these changes occurring during period of brain growth spurt (<2 years age) may be irreversible. Association of iron deficiency with febrile seizures, pica, breath holding spells, restless leg syndrome and thrombosis is increasingly being recognized. Impaired cell-mediated immunity and bactericidal function are generally noted in iron-deficient persons; however, the findings are inconsistent. Despite proven reversible functional immunological defects in vitro studies, a clinically important relationship between states of iron deficiency and susceptibility to infections remains controversial. Studies from malaria endemic regions have reported increased incidence of malaria in association with iron supplementation. These and some other aspects of iron deficiency are reviewed in this article. |
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Authors:
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Dinesh Yadav; Jagdish Chandra |
Publication Detail:
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Type: Journal Article; Review Date: 2010-09-03 |
Journal Detail:
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Title: Indian journal of pediatrics Volume: 78 ISSN: 0973-7693 ISO Abbreviation: Indian J Pediatr Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2011-01-11 Completed Date: 2011-05-03 Revised Date: 2012-03-08 |
Medline Journal Info:
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Nlm Unique ID: 0417442 Medline TA: Indian J Pediatr Country: India |
Other Details:
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Languages: eng Pagination: 65-72 Citation Subset: IM |
Affiliation:
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Department of Pediatrics, Kalawati Saran Children's Hospital and Lady Hardinge Medical College, New Delhi, India. dineshmamc@gmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Anemia, Iron-Deficiency Child, Preschool Deficiency Diseases / complications Humans Infant Iron / deficiency* |
| Chemical | |
Reg. No./Substance:
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7439-89-6/Iron |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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