Document Detail

Iron deficiency anemia and cognitive function in infancy.
MedLine Citation:
PMID:  20660551     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: This study examined effects of iron deficiency anemia (IDA) on specific domains of infant cognitive function and the role of IDA-related socioemotional deficits in mediating and/or moderating these effects.
METHODS: Infants were recruited during routine 9-month visits to an inner-city clinic. IDA was defined as hemoglobin level <110 g/L with > or =2 abnormal iron deficiency indicators (mean corpuscular volume, red cell distribution width, zinc protoporphyrin, transferrin saturation, and ferritin). At 9 and 12 months, the Fagan Test of Infant Intelligence (FTII); A-not-B task; Emotionality, Activity, and Sociability Temperament Survey; and Behavior Rating Scale were administered. Analyses were adjusted for potential confounders, including age and sociodemographic variables.
RESULTS: Twenty-eight infants met criteria for IDA, 28 had nonanemic iron deficiency (NA ID) and 21 had iron sufficiency (IS). There was a linear effect for object permanence at 9 months: infants with IDA were least likely to exhibit object permanence, IS most likely, and NA ID intermediate. Infants with IDA and those with hemoglobin level < or =105 g/L showed poorer recognition memory on the FTII than infants without IDA. The Behavior Rating Scale orientation/engagement measure partially mediated these effects. Stronger effects of IDA on these outcomes were seen in infants who scored more poorly on the socioemotional measures.
CONCLUSIONS: These data indicate poorer object permanence and short-term memory encoding and/or retrieval in infants with IDA at 9 months. These cognitive effects were attributable, in part, to IDA-related deficits in socioemotional function. Children with poor socioemotional performance seem to be more vulnerable to the effects of IDA on cognitive function.
R Colin Carter; Joseph L Jacobson; Matthew J Burden; Rinat Armony-Sivan; Neil C Dodge; Mary Lu Angelilli; Betsy Lozoff; Sandra W Jacobson
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2010-07-26
Journal Detail:
Title:  Pediatrics     Volume:  126     ISSN:  1098-4275     ISO Abbreviation:  Pediatrics     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-08-03     Completed Date:  2010-09-02     Revised Date:  2014-09-08    
Medline Journal Info:
Nlm Unique ID:  0376422     Medline TA:  Pediatrics     Country:  United States    
Other Details:
Languages:  eng     Pagination:  e427-34     Citation Subset:  AIM; IM    
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MeSH Terms
Anemia, Iron-Deficiency / epidemiology*
Cognition Disorders / diagnosis*,  epidemiology*
Mood Disorders / diagnosis,  epidemiology*,  psychology
Neuropsychological Tests
Play and Playthings
Recognition (Psychology)
Severity of Illness Index
Social Behavior
Grant Support
P01 HD039386/HD/NICHD NIH HHS; P01 HD039386-01A1/HD/NICHD NIH HHS; P01 HD039386-02/HD/NICHD NIH HHS; P01 HD039386-03/HD/NICHD NIH HHS; P01 HD039386-04/HD/NICHD NIH HHS; P01 HD039386-05/HD/NICHD NIH HHS; P01 HD039386-06A1/HD/NICHD NIH HHS; P01 HD039386-07/HD/NICHD NIH HHS; P01 HD039386-08/HD/NICHD NIH HHS; P01 HD039386-08S1/HD/NICHD NIH HHS; P01 HD039386-09/HD/NICHD NIH HHS; P01 HD039386-10/HD/NICHD NIH HHS; P01 HD39386/HD/NICHD NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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