Document Detail


Iron and CF-related anemia: expanding clinical and biochemical relationships.
MedLine Citation:
PMID:  20963784     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
INTRODUCTION: This cross-sectional study was conducted to assess the relationship between iron levels in the plasma and sputum of cystic fibrosis (CF) patients.
METHODS: Demographic, clinical, and iron-related laboratory data were prospectively obtained from 25 patients with stable clinical features and 14 patients with worsened clinical features since their most recent evaluations.
RESULTS: Compared to patients with stable clinical features, those who experienced clinical deterioration demonstrated significantly worse lung function and were more frequently malnourished and diabetic. Members of the latter group were also significantly more hypoferremic and had higher sputum iron content than patients with stable clinical features. No significant correlation was found between plasma and sputum iron levels when the groups were analyzed together and separately.
CONCLUSIONS: Sputum iron content does not correlate with iron-related hematologic tests. Hypoferremia is common in CF and correlates with poor lung function and overall health.
Authors:
A H Gifford; S D Miller; B P Jackson; T H Hampton; G A O'Toole; B A Stanton; H W Parker
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2010-10-20
Journal Detail:
Title:  Pediatric pulmonology     Volume:  46     ISSN:  1099-0496     ISO Abbreviation:  Pediatr. Pulmonol.     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-01-24     Completed Date:  2011-05-19     Revised Date:  2014-09-18    
Medline Journal Info:
Nlm Unique ID:  8510590     Medline TA:  Pediatr Pulmonol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  160-5     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Wiley-Liss, Inc.
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MeSH Terms
Descriptor/Qualifier:
Adult
Anemia / etiology
Cross-Sectional Studies
Cystic Fibrosis / blood,  complications,  physiopathology*
Diabetes Mellitus / etiology
Female
Humans
Iron / blood*
Iron, Dietary / blood
Lung / physiopathology*
Male
Middle Aged
Prospective Studies
Sputum / chemistry
Young Adult
Grant Support
ID/Acronym/Agency:
P20 RR-018787/RR/NCRR NIH HHS; P20 RR018787/RR/NCRR NIH HHS; P42 ES007373/ES/NIEHS NIH HHS; R01 AI083256/AI/NIAID NIH HHS; R01 HL074175/HL/NHLBI NIH HHS; R01-HL074175-04-06/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Iron, Dietary; E1UOL152H7/Iron
Comments/Corrections

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