| Iron and CF-related anemia: expanding clinical and biochemical relationships. | |
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MedLine Citation:
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PMID: 20963784 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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INTRODUCTION: This cross-sectional study was conducted to assess the relationship between iron levels in the plasma and sputum of cystic fibrosis (CF) patients. METHODS: Demographic, clinical, and iron-related laboratory data were prospectively obtained from 25 patients with stable clinical features and 14 patients with worsened clinical features since their most recent evaluations. RESULTS: Compared to patients with stable clinical features, those who experienced clinical deterioration demonstrated significantly worse lung function and were more frequently malnourished and diabetic. Members of the latter group were also significantly more hypoferremic and had higher sputum iron content than patients with stable clinical features. No significant correlation was found between plasma and sputum iron levels when the groups were analyzed together and separately. CONCLUSIONS: Sputum iron content does not correlate with iron-related hematologic tests. Hypoferremia is common in CF and correlates with poor lung function and overall health. |
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Authors:
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A H Gifford; S D Miller; B P Jackson; T H Hampton; G A O'Toole; B A Stanton; H W Parker |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2010-10-20 |
Journal Detail:
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Title: Pediatric pulmonology Volume: 46 ISSN: 1099-0496 ISO Abbreviation: Pediatr. Pulmonol. Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-01-24 Completed Date: 2011-05-19 Revised Date: 2013-04-17 |
Medline Journal Info:
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Nlm Unique ID: 8510590 Medline TA: Pediatr Pulmonol Country: United States |
Other Details:
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Languages: eng Pagination: 160-5 Citation Subset: IM |
Copyright Information:
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Copyright © 2011 Wiley-Liss, Inc. |
Affiliation:
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Section of Pulmonary and Critical Care Medicine, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire. giffora@hitchcock.org |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Anemia / etiology Cross-Sectional Studies Cystic Fibrosis / blood, complications, physiopathology* Diabetes Mellitus / etiology Female Humans Iron / blood* Iron, Dietary / blood Lung / physiopathology* Male Middle Aged Prospective Studies Sputum / chemistry Young Adult |
| Grant Support | |
ID/Acronym/Agency:
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P20 RR-018787/RR/NCRR NIH HHS; P20 RR018787/RR/NCRR NIH HHS; P42 ES007373/ES/NIEHS NIH HHS; R01 AI083256/AI/NIAID NIH HHS; R01 HL074175/HL/NHLBI NIH HHS; R01 HL074175-07/HL/NHLBI NIH HHS; R01-HL074175-04-06/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Iron, Dietary; 7439-89-6/Iron |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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