Document Detail


Irisin mRNA and circulating levels in relation to other myokines in healthy and morbidly obese humans.
MedLine Citation:
PMID:  24062354     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: Skeletal muscle is considered to be an endocrine organ that secretes a number of myokines including follistatin (FST), myostatin (MSTN), activin A, and the newly identified irisin. Irisin's biology and function exhibit similarities with the functions of the FST-MSTN-activin A axis. It remains unknown whether there is any interplay among these molecules. The aim of this study is to examine potential associations of irisin with the FST, MSTN, and activin A axis.
METHODS: Two observational studies were performed to evaluate the associations of irisin with the other three peptides. Study A included 150 healthy males aged 18.48±0.16 years with BMI 23.18±3.75 kg/m(2). Fasting serum samples were used to measure the levels of the molecules of interest. Study B included 14 morbidly obese individuals, candidates for bariatric surgery, aged 53.14±8.93 years with BMI 50.18±10.63 kg/m(2). Blood samples were obtained after an overnight fast. Eight out of the 14 participants consented to an optional thigh biopsy during their bariatric surgery. Using the above blood and tissue samples, we measured circulating levels and muscle mRNA of irisin, FST, MSTN, and activin A.
RESULTS: We report that FNDC5 mRNA in muscle is positively correlated with FST mRNA expression in morbidly obese subjects (ρ=0.93, P<0.001). We also found that circulating irisin is positively correlated with FST circulating levels among lean subjects (ρ=0.17, P=0.05) while this association was suggestive among the obese (ρ=0.56, P=0.07).
CONCLUSION: The newly identified myokine irisin may be positively associated with FST at both the mRNA and circulating protein level.
Authors:
Maria T Vamvini; Konstantinos N Aronis; Grigorios Panagiotou; Joo Young Huh; John P Chamberland; Mary T Brinkoetter; Michael Petrou; Costas A Christophi; Stefanos N Kales; David C Christiani; Christos S Mantzoros
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Publication Detail:
Type:  Journal Article; Observational Study; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2013-10-21
Journal Detail:
Title:  European journal of endocrinology / European Federation of Endocrine Societies     Volume:  169     ISSN:  1479-683X     ISO Abbreviation:  Eur. J. Endocrinol.     Publication Date:  2013 Dec 
Date Detail:
Created Date:  2013-10-22     Completed Date:  2013-12-16     Revised Date:  2014-01-30    
Medline Journal Info:
Nlm Unique ID:  9423848     Medline TA:  Eur J Endocrinol     Country:  England    
Other Details:
Languages:  eng     Pagination:  829-34     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Activins / blood*,  genetics
Adult
Aged
Body Mass Index
Cross-Sectional Studies
Cyprus
Female
Fibronectins / blood*,  genetics
Follistatin / blood*,  genetics
Humans
Male
Middle Aged
Muscle, Skeletal / metabolism*
Myostatin / blood*,  genetics
Obesity, Morbid / blood*,  metabolism
PPAR gamma / blood
RNA, Messenger / blood
Real-Time Polymerase Chain Reaction
Transcription Factors / blood
Grant Support
ID/Acronym/Agency:
AG032030/AG/NIA NIH HHS; DK058785/DK/NIDDK NIH HHS; DK079929/DK/NIDDK NIH HHS; DK081913/DK/NIDDK NIH HHS; K24 DK081913/DK/NIDDK NIH HHS; R01 AG032030/AG/NIA NIH HHS; R01 DK058785/DK/NIDDK NIH HHS; R01 DK079929/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
0/FNDC5 protein, human; 0/FST protein, human; 0/Fibronectins; 0/Follistatin; 0/MSTN protein, human; 0/Myostatin; 0/PPAR gamma; 0/PPARGC1A protein, human; 0/RNA, Messenger; 0/Transcription Factors; 0/activin A; 104625-48-1/Activins
Comments/Corrections
Comment In:
Nat Rev Endocrinol. 2014 Jan;10(1):11-2   [PMID:  24247218 ]

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