| Iridium-192 brachytherapy in combination with interstitial microwave-induced hyperthermia for malignant glioma. | |
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MedLine Citation:
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PMID: 3329865 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A phase I clinical trial assessing the feasibility and safety of hyperthermia in combination with 192Ir brachytherapy (60 Gy) for the treatment of malignant glioma now includes 14 patients. Hyperthermia (42-43 degrees C at tumor margin for 60 min) has been induced using stereotactically implanted afterloading catheters and a microwave (915 or 2,450 MHz) antenna array. Thermometry recorded along each catheter confirms the general ability of the technique to heat such volumes, but thermal heterogeneities are documented. Transient or permanent worsening of previous neurologic deficit, seen in 7 patients, has been the most common morbidity. |
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Authors:
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D W Roberts; J W Strohbehn; C T Coughlin; T P Ryan; B E Lyons; E B Douple |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Applied neurophysiology Volume: 50 ISSN: 0302-2773 ISO Abbreviation: Appl Neurophysiol Publication Date: 1987 |
Date Detail:
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Created Date: 1988-06-23 Completed Date: 1988-06-23 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 7600656 Medline TA: Appl Neurophysiol Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 287-91 Citation Subset: IM |
Affiliation:
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Dartmouth-Hitchcock Medical Center, Dartmouth College, Hanover, N.H. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Brachytherapy* Brain Neoplasms / radiotherapy* Combined Modality Therapy Glioma / radiotherapy* Humans Hyperthermia, Induced* Iridium Radioisotopes / therapeutic use* Microwaves / therapeutic use* Middle Aged Stereotaxic Techniques* |
| Grant Support | |
ID/Acronym/Agency:
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CA23108/CA/NCI NIH HHS; CA23594/CA/NCI NIH HHS; CA42604/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Iridium Radioisotopes |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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