| Ir(I)-Catalyzed C-H Bond Alkylation of C2-Position of Indole with Alkenes: Selective Synthesis of Linear or Branched 2-Alkylindoles. | |
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MedLine Citation:
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PMID: 23043316 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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We here disclosed that the first example of direct C-H bond alkylation of "C2 position" of indole in the cationic iridium-catalyzed reaction with various alkenes. The choice of protecting group (acetyl or benzoyl group) of nitrogen-atom and ligand on Ir (BINAP derivatives or SDP) control the linear/branched selectivity. As for alkenes, in addition to various styrene derivatives and an acrylate, even a simple alkene can be used. |
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Authors:
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Shiguang Pan; Naoto Ryu; Takanori Shibata |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-10-9 |
Journal Detail:
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Title: Journal of the American Chemical Society Volume: - ISSN: 1520-5126 ISO Abbreviation: J. Am. Chem. Soc. Publication Date: 2012 Oct |
Date Detail:
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Created Date: 2012-10-9 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7503056 Medline TA: J Am Chem Soc Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
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