Document Detail

Ir(I)-Catalyzed C-H Bond Alkylation of C2-Position of Indole with Alkenes: Selective Synthesis of Linear or Branched 2-Alkylindoles.
MedLine Citation:
PMID:  23043316     Owner:  NLM     Status:  Publisher    
We here disclosed that the first example of direct C-H bond alkylation of "C2 position" of indole in the cationic iridium-catalyzed reaction with various alkenes. The choice of protecting group (acetyl or benzoyl group) of nitrogen-atom and ligand on Ir (BINAP derivatives or SDP) control the linear/branched selectivity. As for alkenes, in addition to various styrene derivatives and an acrylate, even a simple alkene can be used.
Shiguang Pan; Naoto Ryu; Takanori Shibata
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-10-9
Journal Detail:
Title:  Journal of the American Chemical Society     Volume:  -     ISSN:  1520-5126     ISO Abbreviation:  J. Am. Chem. Soc.     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-9     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7503056     Medline TA:  J Am Chem Soc     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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