| Ipsilateral motor-related hyperactivity in patients with cerebral occlusive vascular disease. | |
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MedLine Citation:
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PMID: 18635836 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND AND PURPOSE: Cerebral occlusive vascular disease is an established risk factor for ischemic stroke; however, little is known about its effects on brain function in patients without stroke. To detect possible functional alterations, we used magnetoencephalography and evaluated cerebral cortical activity during hand motor tasks in a group of such patients. Method- Event-related desynchronization (ERD) during hand-grasping and self-paced finger-tapping tasks was examined in 38 right-hand-dominant patients with occlusive disease of the internal carotid or middle cerebral artery caused by diverse pathologies (atherosclerosis, 28; others, 10) and in 8 control subjects. All patients had no apparent motor impairments. The spatial distribution and the intensity (t value) of ERD in the beta band were analyzed with synthetic aperture magnetometry. According to the laterality index calculated from the ratios of peak t values on ipsilateral vs contralateral (with respect to the hand movement) hemispheres, the distribution of ERD was classified into 3 patterns: contralateral, bilateral, and ipsilateral. RESULTS: Abnormal ipsilateral dominant distribution of beta ERD was observed significantly more often during contralesional hand grasping in patients with atherosclerotic vascular lesion. It was accompanied by significantly higher t values on the ipsilateral hemisphere, without a decrease in those on the contralateral side. The age, the rating scores of periventricular hyperintensity, and ventricular size were all significantly higher in patients who showed the ipsilateral-dominant pattern. CONCLUSIONS: Abnormal ipsilateral hyperactivity may indicate the presence of subclinical functional alterations related to atherosclerotic occlusive vascular disease. |
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Authors:
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Satoru Oshino; Amami Kato; Masayuki Hirata; Haruhiko Kishima; Youichi Saitoh; Toshiyuki Fujinaka; Toshiki Yoshimine |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2008-07-17 |
Journal Detail:
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Title: Stroke; a journal of cerebral circulation Volume: 39 ISSN: 1524-4628 ISO Abbreviation: Stroke Publication Date: 2008 Oct |
Date Detail:
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Created Date: 2008-09-30 Completed Date: 2008-10-21 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0235266 Medline TA: Stroke Country: United States |
Other Details:
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Languages: eng Pagination: 2769-75 Citation Subset: IM |
Affiliation:
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Department of Neurosurgery, Osaka University Graduate School of Medicine, Suita, Osaka, Japan. s-oshino@nsurg.med.osaka-u.ac.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Carotid Artery Diseases / complications Cerebrovascular Circulation / physiology Cerebrovascular Disorders / complications* Cortical Synchronization Female Functional Laterality / physiology* Humans Hyperkinesis / etiology* Magnetoencephalography Male Middle Aged Middle Cerebral Artery / pathology Tomography, Emission-Computed, Single-Photon |
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