Document Detail


Ipsilateral activation of the unaffected motor cortex in patients with hemiparetic stroke.
MedLine Citation:
PMID:  11068234     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND AND PURPOSE: Recent research has shown that following stroke patients can display ipsilateral activity reflecting a functional link between the undamaged hemisphere and the affected upper limb on the same side of the body. In the present study the capacity for ipsilateral activation is documented during recovery by using transcranial magnetic stimulation (TMS) and transcranial Doppler (TCD). METHODS: Fourteen patients affected by hemispheric stroke were examined with TMS and TCD within 48 h of onset, and again 6 months later. Neurological signs were scored with reference to the NIHSS, and patients executed a thumb to finger opposition task so as to further estimate the motor deficit. Twenty healthy volunteers represented the control population. RESULTS: (1) Both TMS and TCD yielded homogeneous results showing ipsilateral activity between affected hands and undamaged hemispheres. On stimulating the motor cortex 3 cm anterior and 3 cm lateral to Cz, a scalp site remote from the primary motor area, ipsilateral motor evoked potentials (iMEPs) from hand muscles were found in recovered patients. (2) In 8 controls iMEPs with smaller amplitudes than patients could be obtained by stimulating only the left hemisphere. (3) TCD revealed increased blood flow velocity in the ipsilateral MCA by activating the recovering hand (10.5+/-3.3%; P<0.001). CONCLUSION: TMS reveals a specific area in the motor cortex from which ipsilateral MEPs can be elicited and both TMS and TCD indicate that an ipsilateral corticospinal tract can be accessible in some adult controls or becomes unmasked after cerebral damage.
Authors:
M D Caramia; M G Palmieri; P Giacomini; C Iani; L Dally; M Silvestrini
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology     Volume:  111     ISSN:  1388-2457     ISO Abbreviation:  Clin Neurophysiol     Publication Date:  2000 Nov 
Date Detail:
Created Date:  2000-12-15     Completed Date:  2001-01-11     Revised Date:  2008-09-10    
Medline Journal Info:
Nlm Unique ID:  100883319     Medline TA:  Clin Neurophysiol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  1990-6     Citation Subset:  IM    
Affiliation:
Clinica Neurologica, Dipartimento di Neuroscienze, Università di Tor Vergata, Roma, Italy. mwjones@ats.it
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MeSH Terms
Descriptor/Qualifier:
Aged
Electroencephalography
Evoked Potentials, Motor / physiology
Female
Functional Laterality / physiology*
Humans
Magnetics
Male
Middle Aged
Motor Cortex / physiopathology*
Paresis / physiopathology*
Stroke / physiopathology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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