Document Detail

Ipsilateral double parathyroid adenoma and thyroid hemiagenesis.
MedLine Citation:
PMID:  20733341     Owner:  NLM     Status:  MEDLINE    
BACKGROUND/AIMS: To describe a case of left thyroid dysgenesis, accompanied by ipsilateral double parathyroid adenomas in a setting of primary hyperparathyroidism, and to review the pertinent literature on the diagnosis of these rare clinical scenarios.
METHODS: Review of the English literature with addition of a case report.
RESULTS: Preoperative evaluation included both sestamibi and ultrasound evaluation of the neck. Fine-needle aspiration biopsies of what was thought to be two concerning thyroid nodules revealed potential double intrathyroidal parathyroid adenomas. Video-assisted exploration verified double parathyroid adenomas and revealed concomitant left thyroid lobe dysgenesis. Intact parathyroid hormone level returned to normal and a greater than 50% drop from baseline was achieved intraoperatively with subsequent long-term cure.
CONCLUSIONS: Thyroid dysgenesis is a rare, poorly understood and potentially confusing variety of developmental anomalies, which can be associated with thyroid as well as parathyroid disease. Clinical diagnosis is highly dependent upon the clinician maintaining an index of suspicion for these anomalies, thorough physical examination and careful review of available imaging modalities, especially while investigating thyroid and parathyroid disorders.
W K Mydlarz; K Zhang; S T Micchelli; M Kim; R P Tufano
Publication Detail:
Type:  Case Reports; Journal Article     Date:  2010-08-21
Journal Detail:
Title:  ORL; journal for oto-rhino-laryngology and its related specialties     Volume:  72     ISSN:  1423-0275     ISO Abbreviation:  ORL J. Otorhinolaryngol. Relat. Spec.     Publication Date:  2010  
Date Detail:
Created Date:  2010-09-10     Completed Date:  2010-12-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0334721     Medline TA:  ORL J Otorhinolaryngol Relat Spec     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  272-4     Citation Subset:  IM    
Department of Otolaryngology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
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MeSH Terms
Adenoma / complications,  diagnosis*
Hyperparathyroidism, Primary / complications,  diagnosis*
Middle Aged
Parathyroid Neoplasms / complications,  diagnosis*
Thyroid Dysgenesis / complications,  diagnosis*
Thyroid Gland / abnormalities*,  radionuclide imaging,  ultrasonography

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