Document Detail


IPROVERATRIL: EXPERIMENTAL DATA ON CORONARY DILATATION AND ANTIARRHYTHMIC ACTION.
MedLine Citation:
PMID:  14132168     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Various cardiovascular effects of a new synthetic coronary vasodilator, alpha-isopropyl-alpha [(N-methyl - N - homoveratryl)-gamma-amino-propyl]-3, 4-dimethoxyphenylacetonitrile HCI (D365, Iproveratril or Isoptin) have been studied. In isolated perfused rabbit hearts the drug exerts a potent coronary vasodilator action, but can depress myocardial contractions and A-V conduction. In anesthetized cats it produces varying degrees of hypotension with bradycardia, and antagonizes ST-T changes induced by ouabain. It can also protect against chloroform-adrenaline and ouabain ventricular fibrillation. On isolated papillary muscle preparations it can lead to adrenergic blockade. It is concluded that in addition to its coronary dilator action, the drug exerts ;quinidine-like' antiarrythmic effects, and appears to deserve further study.
Authors:
K I MELVILLE; H E SHISTER; S HUQ
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Canadian Medical Association journal     Volume:  90     ISSN:  0008-4409     ISO Abbreviation:  Can Med Assoc J     Publication Date:  1964 Mar 
Date Detail:
Created Date:  1964-08-01     Completed Date:  1996-12-01     Revised Date:  2011-09-28    
Medline Journal Info:
Nlm Unique ID:  0414110     Medline TA:  Can Med Assoc J     Country:  CANADA    
Other Details:
Languages:  eng     Pagination:  761-70     Citation Subset:  OM    
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MeSH Terms
Descriptor/Qualifier:
Anti-Arrhythmia Agents*
Anura*
Blood Pressure*
Bradycardia*
Cats*
Chloroform*
Coronary Vessels*
Electrocardiography*
Epinephrine*
Heart*
Hypotension*
Ouabain*
Pharmacology*
Rabbits*
Research*
Strophanthins*
Toxicology*
Vasodilator Agents*
Verapamil*
Chemical
Reg. No./Substance:
0/Anti-Arrhythmia Agents; 0/Strophanthins; 0/Vasodilator Agents; 51-43-4/Epinephrine; 52-53-9/Verapamil; 630-60-4/Ouabain; 67-66-3/Chloroform
Comments/Corrections

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