| Ipilimumab therapy for advanced melanoma is associated with secondary adrenal insufficiency: a case series. | |
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MedLine Citation:
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PMID: 22138079 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Objective: To present seven cases of ipilimumab-related secondary adrenal insufficiency.Methods: The presentation, evaluation, diagnosis and management are reviewed for seven patients with advanced melanoma who received ipilimumab and were referred to our endocrinology clinic for evaluation of hormonal abnormalities.Results: Patients presented with symptoms, signs, or biochemical evidence of adrenal insufficiency 6-12 weeks after starting ipilimumab therapy. All seven patients had biochemical evidence of profound secondary adrenal insufficiency. Abnormalities in thyroid function tests, central hypogonadism, and low IGF-1 levels were seen in a subset of patients. Only two patients had abnormal findings on pituitary magnetic resonance imaging (MRI). Posterior pituitary function remained normal.Conclusion: Ipilimumab is a CTLA4 monoclonal antibody that is approved for the treatment of metastatic melanoma and has widespread use for this disease. Herein we report the association of secondary adrenal insufficiency while on ipilimumab therapy. We recommend periodic hypothalamic-pituitary-adrenal axis monitoring for patients on this therapy. |
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Authors:
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Le Min; Anand Vaidya; Carolyn Becker |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-12-2 |
Journal Detail:
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Title: Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists Volume: - ISSN: 1934-2403 ISO Abbreviation: - Publication Date: 2011 Dec |
Date Detail:
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Created Date: 2011-12-5 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9607439 Medline TA: Endocr Pract Country: - |
Other Details:
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Languages: ENG Pagination: 1-13 Citation Subset: - |
Affiliation:
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Division of Endocrinology, Diabetes, and Hypertension, Brigham and Women's Hospital, Harvard Medical School, 221 Longwood Avenue, Boston, 02115. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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