| Iontophoretic permeability of polyethylene glycols through hairless rat skin: application of hydrodynamic theory for hindered transport through liquid-filled pores. | |
| | |
MedLine Citation:
|
PMID: 1525303 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The electrically-assisted transport of a homologous series of polyethylene glycols (PEGs) through hairless rat skin (HRS) was examined in order to determine the relationship between the iontophoretic permeability of flexible macromolecules and their size and conformation in free solution. Using fully hydrated HRS, the anodic transport of 26 low molecular weight oligomers of PEG was studied over a 14 hour period at a current density of 0.50 mA/cm2. Analysis of the data revealed a distinct sigmoidal relationship between iontophoretic permeability and molecular size. In addition, the reflection of a relatively small molecular weight species was significant. Accordingly, a hydrodynamic model relating the convective transport of flexible macrosolutes through cylindrical pores was fit to the data generated from the iontophoretic transport of PEGs ranging in weight from 282 to 1382 daltons. A nonlinear least squares analysis of the data demonstrated that the 'effective' mean diameter of aqueous channels within HRS is approximately 36 A. |
| | |
Authors:
|
S B Ruddy; B W Hadzija |
Related Documents
:
|
19400573 - Cationic comb polymer superdispersants for colloidal silica suspensions. 17391003 - Synthesis and characterization of novel poly[(organo)phosphazenes] with cell-adhesive s... 10552133 - Drought stress syndrome in wheat is provoked by ethylene evolution imbalance and revers... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Drug design and discovery Volume: 8 ISSN: 1055-9612 ISO Abbreviation: Drug Des Discov Publication Date: 1992 Feb |
Date Detail:
|
Created Date: 1992-10-19 Completed Date: 1992-10-19 Revised Date: 2008-11-21 |
Medline Journal Info:
|
Nlm Unique ID: 9200627 Medline TA: Drug Des Discov Country: SWITZERLAND |
Other Details:
|
Languages: eng Pagination: 207-24 Citation Subset: IM; S |
Affiliation:
|
Division of Pharmaceutics, School of Pharmacy, University of North Carolina, Chapel Hill 27599. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Chromatography, High Pressure Liquid Electrophysiology Iontophoresis / methods* Macromolecular Substances Male Mathematical Computing Models, Biological Permeability Polyethylene Glycols / pharmacokinetics* Rats Rats, Nude Skin / metabolism* Skin Physiological Phenomena Solutions |
| Chemical | |
Reg. No./Substance:
|
0/Macromolecular Substances; 0/Polyethylene Glycols; 0/Solutions |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: The cytotoxicity of helenalin, its mono and difunctional esters, and related sesquiterpene lactones ...
Next Document: Synthesis and biological activity of uronic acid analogues of 2-5A[5'-O-triphosphoryladenylyl(2----5...