Document Detail

Iontophoretic delivery of terbinafine in onychomycosis: a preliminary study.
MedLine Citation:
PMID:  19785609     Owner:  NLM     Status:  MEDLINE    
Background Onychomycosis is a common disease; topical treatment is usually poorly effective, while systemic treatment is more effective but may be associated with side-effects. Iontophoretic drug delivery may improve drug penetration through the nail and lead to better therapeutic results. Objectives To evaluate the efficacy, safety and tolerability of topical treatments with terbinafine HCl delivered with or without an iontophoretic patch in patients with onychomycosis of the toenails. Methods Patients enrolled into the study were divided randomly into two groups. Group A was treated with terbinafine and an iontophoretic patch (at a constant current density of 100 microA cm(-2)). Group B was treated with terbinafine without iontophoresis. Treatment was overnight wear, every day, 5 days per week, for 4 weeks. Follow-up period was 8 weeks from the end of treatment. Results A significant clinical response was recorded in patients of group A (active group). The percentage of patients having healthy toenail growth of more than 1.5 mm at the end of treatment was 40% compared with 11% in patients treated with terbinafine without current (passive group). The percentage of patients having fungal elements (KOH) in nail specimens decreased significantly at 8 weeks following the completion of treatment: 16% in the active group vs. 53% in the passive group. Patients in the active group reported a tingling sensation that is expected when using an iontophoretic drug delivery treatment. Conclusions The delivery of terbinafine under an electrical current of 100 microA cm(-2) appears to be efficacious and safe and is well tolerated for the treatment of nail onychomycosis.
B Amichai; B Nitzan; R Mosckovitz; A Shemer
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial     Date:  2009-07-20
Journal Detail:
Title:  The British journal of dermatology     Volume:  162     ISSN:  1365-2133     ISO Abbreviation:  Br. J. Dermatol.     Publication Date:  2010 Jan 
Date Detail:
Created Date:  2010-04-06     Completed Date:  2010-05-24     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0004041     Medline TA:  Br J Dermatol     Country:  England    
Other Details:
Languages:  eng     Pagination:  46-50     Citation Subset:  IM    
Department of Dermatology, Sheba Medical Center, Tel-Hashomer, Israel.
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MeSH Terms
Antifungal Agents / administration & dosage*
Foot Dermatoses / drug therapy*,  microbiology
Middle Aged
Nails / growth & development
Naphthalenes / administration & dosage*
Onychomycosis / drug therapy*,  microbiology
Young Adult
Reg. No./Substance:
0/Antifungal Agents; 0/Naphthalenes; 91161-71-6/terbinafine
Comment In:
Br J Dermatol. 2010 Mar;162(3):699-700   [PMID:  20030642 ]

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