Document Detail

Ionotropic glutamate receptors: genetics, behavior and electrophysiology.
MedLine Citation:
PMID:  18050468     Owner:  NLM     Status:  MEDLINE    
Most rapid excitatory synaptic signaling is mediated by glutamatergic neurotransmission. An important challenge in neurobiology is to understand the molecular architecture of functional glutamatergic synapses. By combining the techniques of genetics, molecular biology and electrophysiology in C. elegans we have the potential to identify and characterize the molecules that contribute to the function of glutamatergic synapses. In C. elegans both excitatory and inhibitory ionotropic glutamate receptors are linked to neural circuits and behavior. Genetic analysis has identified genes required for receptor expression, trafficking, localization, stabilization and function at synapses. Significantly, novel proteins required for glutamate receptor function have been discovered in the worm. These advances may also lead to a better understanding of glutamatergic signaling in vertebrates.
Penelope J Brockie; Andres V Maricq
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Review     Date:  2006-01-19
Journal Detail:
Title:  WormBook : the online review of C. elegans biology     Volume:  -     ISSN:  1551-8507     ISO Abbreviation:  WormBook     Publication Date:  2006  
Date Detail:
Created Date:  2007-11-30     Completed Date:  2008-01-02     Revised Date:  2012-10-09    
Medline Journal Info:
Nlm Unique ID:  101303985     Medline TA:  WormBook     Country:  Unknown    
Other Details:
Languages:  eng     Pagination:  1-16     Citation Subset:  IM    
Department of Biology, University of Utah, Salt Lake City, Utah 84112-0840, USA.
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MeSH Terms
Behavior, Animal / physiology
Caenorhabditis elegans / physiology*
Chloride Channels / physiology
Nervous System Physiological Phenomena
Receptors, Glutamate / genetics,  physiology*
Signal Transduction
Grant Support
Reg. No./Substance:
0/Chloride Channels; 0/Receptors, Glutamate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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