Document Detail

Ionophore A23187 and dibutyryl cyclic AMP effects on cell shape and morphology of B-16 melanoma.
MedLine Citation:
PMID:  188229     Owner:  NLM     Status:  MEDLINE    
Melanoma cells treated with dibutyryl cyclic AMP (db cAMP) for 24 h resulted in dendritic cells possessing parallel assembled microtubules. A23187 treatments resulted in a biphasic response: Long term effects of the ionophore were characterized by small epitheloid cells while the immediate response produced elongated cells with parallel arranged 10 nm microgilaments, characteristic of dispersive melanocytes.
J J Sauk
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Virchows Archiv. B: Cell pathology     Volume:  22     ISSN:  -     ISO Abbreviation:  Virchows Arch B Cell Pathol     Publication Date:  1976 Dec 
Date Detail:
Created Date:  1977-02-16     Completed Date:  1977-02-16     Revised Date:  2014-07-21    
Medline Journal Info:
Nlm Unique ID:  0437105     Medline TA:  Virchows Arch B Cell Pathol     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  305-13     Citation Subset:  IM    
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MeSH Terms
Anti-Bacterial Agents / pharmacology*
Bucladesine / pharmacology*
Calcimycin / pharmacology*
Calcium / metabolism
Cells, Cultured
Cytoskeleton / ultrastructure
Melanoma / ultrastructure*
Mice, Inbred C57BL
Microscopy, Electron
Microscopy, Electron, Scanning
Microtubules / ultrastructure
Neoplasms, Experimental
Reg. No./Substance:
0/Anti-Bacterial Agents; 37H9VM9WZL/Calcimycin; 63X7MBT2LQ/Bucladesine; SY7Q814VUP/Calcium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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