Document Detail


Ionization, Transport, Separation, and Detection of Ions in Non-Electrolyte Containing Liquids.
MedLine Citation:
PMID:  23092298     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Liquid phase ion mobility spectrometry (LPIMS) has the potential to be miniaturized such that it can be incorporated into chip based technology, providing higher performance in terms of both detection sensitivity and resolving power than is currently available by other separation technologies such as gas phase IMS, chromatography, or electrophoresis. This work presents modeling, simulation, and experimental investigations to characterize the mobility of ions in a liquid phase. This study included the ionization, transfer, separation, and detection of ions in non-electrolyte liquids. Using a resistive glass tube, mobility spectra were obtained by pulsed ionization for several different analytes, namely, tetramethylammonium chloride, tetrabutylammonium chloride, and dimethyl methylphosphonate (DMMP). Ion separation was demonstrated by separating solvent ions from the ions generated from the test compounds. Simulation and theoretical resolving power calculations were made to validate the experimental mobility measurements. A parametric study on the dependence of IMS resolving power on drift length, voltage across drift cell, and pulse width determined the requirements for designing a miniaturized IMS system, approximately the centimeter scale, with high performance, resolving power approaching 100 or higher. Mobility spectra are used for the first time to determine the diffusion coefficients of ions in a liquid.
Authors:
Manuja R Lamabadusuriya; William F Siems; Herbert H Hill; Adrian Mariano; Samar K Guharay
Related Documents :
24448968 - Dimethocaine, a synthetic cocaine analogue: studies on its in-vivo metabolism and its d...
2986478 - Influences of salts on high-performance liquid chromatography of leukotrienes.
15587578 - Quantitative and qualitative hplc analysis of thermogenic weight loss products.
16480728 - High-efficiency liquid chromatography on conventional columns and instrumentation by us...
20977878 - Reversible interference of fe³(+) with monoclonal antibody analysis in cation exchange...
12210508 - Lc-esi-ms analysis of taxoids from the bark of taxus wallichiana.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-10-23
Journal Detail:
Title:  Analytical chemistry     Volume:  -     ISSN:  1520-6882     ISO Abbreviation:  Anal. Chem.     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-24     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370536     Medline TA:  Anal Chem     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Chemistry, Washington State University , Pullman, Washington 99164, United States.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Atorvastatin sensitises vascular smooth muscle cells, but not endothelial cells, to TNF- ? -induced ...
Next Document:  Ferritin ion channel disorder inhibits Fe(II)/O2 reactivity at distant sites.