Document Detail

Ionic flux across canine duodenum. Movement of bicarbonate.
MedLine Citation:
PMID:  20776     Owner:  NLM     Status:  MEDLINE    
Effect of isosmotic biocarbonate-rich solutions on the Brunner's gland area were studied by means of proximal duodenal explants in eight anesthetized dogs. Volume gain occurred with all instillates and varied indirectly with the concentration of the bicarbonate in the instilled solutions. Net bicarbonate gain occurred with instillate of 40 mEq./1.; net insorption occurred with instillates of higher bicarbonate concentration, the rate of which was dependent on the instillate concentration. Insorption of chloride occurred with the lower bicarbonate solutions and enterosorption occurred at higher concentrations. The modification of intraluminal bicarbonate by the proximal duodenal mucosa is important in the regulation of intraduodenal pH and abnormal function of this mechanism may play a role in the pathogenesis of duodenal ulceration because of incomplete hydrochloric acid neutralization.
H S Himal; J Rudick
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of gastroenterology     Volume:  67     ISSN:  0002-9270     ISO Abbreviation:  Am. J. Gastroenterol.     Publication Date:  1977 Jun 
Date Detail:
Created Date:  1977-11-30     Completed Date:  1977-11-30     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0421030     Medline TA:  Am J Gastroenterol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  574-9     Citation Subset:  IM    
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MeSH Terms
Bicarbonates / metabolism*,  secretion
Brunner Glands / metabolism
Chlorides / metabolism
Duodenal Ulcer / etiology
Duodenum / metabolism*,  secretion
Hydrogen-Ion Concentration
Intestinal Mucosa / metabolism
Osmotic Pressure
Potassium / metabolism
Proteins / metabolism
Sodium / metabolism
Reg. No./Substance:
0/Bicarbonates; 0/Chlorides; 0/Ions; 0/Proteins; 7440-09-7/Potassium; 7440-23-5/Sodium

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