| Ionic effect on the binding of bilirubin to the imprinted poly(methacrylic acid-co-ethylene glycol dimethylacrylate). | |
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MedLine Citation:
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PMID: 16674963 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A molecularly imprinted polymer (MIP) capable of detecting bilirubin was successfully synthesized. Bilirubin template was imprinted in poly(methacrylic acid-co-ethylene glycol dimethylacrylate) [poly(MAA-co-EGDMA)]. MAA and EGDMA were used as the monomer and the cross-linker, respectively. The optimal solvent conditions to maintain its stability were discussed. Solvent system based on ethylenediamine tetraacetic acid (EDTA) and ascorbic acid was compared with respect to the stability of bilirubin. pH and bilirubin concentration were both investigated for the bilirubin stability. Blue light as well as aeration was applied to inspect the regarding effects. The cross-linking effect was further confirmed by the thermogravimetric analysis (TGA). The effect of salts, such as NaCl and KCl on the binding capacity of the molecularly imprinted polymer was also discussed. Further, the rat serum and bile samples were applied and the binding of the MIPs for bilirubin was thus confirmed. |
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Authors:
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Mei-Jywan Syu; You-Ming Nian; Yong-Sheun Chang; Xi-Zhang Lin; Shu-Chu Shiesh; Tse-Chuan Chou |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2006-05-03 |
Journal Detail:
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Title: Journal of chromatography. A Volume: 1122 ISSN: 0021-9673 ISO Abbreviation: J Chromatogr A Publication Date: 2006 Jul |
Date Detail:
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Created Date: 2006-07-10 Completed Date: 2006-09-28 Revised Date: 2009-01-15 |
Medline Journal Info:
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Nlm Unique ID: 9318488 Medline TA: J Chromatogr A Country: Netherlands |
Other Details:
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Languages: eng Pagination: 54-62 Citation Subset: IM |
Affiliation:
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Department of Chemical Engineering, National Cheng Kung University, Tainan 701, Taiwan. syumj@mail.ncku.edu.tw |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adsorption
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drug effects Animals Bile / chemistry Bilirubin / analysis, chemistry* Calibration Cross-Linking Reagents / chemistry Dose-Response Relationship, Drug Drug Stability Ethylene Glycol / chemistry* Light Methacrylates / chemistry* Molecular Structure Polymers / chemical synthesis, chemistry* Potassium Chloride / pharmacology Rats Reproducibility of Results Serum / chemistry Sodium Chloride / pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Cross-Linking Reagents; 0/Methacrylates; 0/Polymers; 107-21-1/Ethylene Glycol; 635-65-4/Bilirubin; 7447-40-7/Potassium Chloride; 7647-14-5/Sodium Chloride; 79-41-4/methacrylic acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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