| Ionic complexes of biosynthetic poly(malic acid) and poly(glutamic acid) as prospective drug-delivery systems. | |
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MedLine Citation:
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PMID: 17599336 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The hydrolytic degradability and erythromycin release from stoichiometric ionic complexes of biotechnological poly(beta,L-malic acid)s and poly(gamma,D-glutamic acid)s with alkyltrimethylammonium surfactants were investigated. The influence of pH, temperature and antibiotic load on hydrolysis rate was examined. It was found that poly(malic acid) complexes degraded by a surface erosion mechanism at a higher rate than poly(glutamic acid) complexes, which eroded in bulk. Erythromycin was lodged in the paraffinic subphase of the complexes and upon aging it was delivered according to a sigmoidal profile that appeared to be independent on the antibiotic load. |
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Authors:
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Jose A Portilla-Arias; Montserrat García-Alvarez; Antxon Martínez de Ilarduya; Sebastián Muñoz-Guerra |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Macromolecular bioscience Volume: 7 ISSN: 1616-5187 ISO Abbreviation: Macromol Biosci Publication Date: 2007 Jul |
Date Detail:
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Created Date: 2007-07-16 Completed Date: 2007-11-02 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101135941 Medline TA: Macromol Biosci Country: Germany |
Other Details:
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Languages: eng Pagination: 897-906 Citation Subset: IM |
Affiliation:
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Departament d'Enginyeria Química, Universitat Politècnica de Catalunya, ETSEIB, Diagonal 647, Barcelona 08028, Spain. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Drug Carriers
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chemistry,
pharmacokinetics* Erythromycin / administration & dosage Hydrogen-Ion Concentration Hydrolysis Ions Kinetics Malates* Materials Testing Polyglutamic Acid* Polymers* Temperature |
| Chemical | |
Reg. No./Substance:
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0/Drug Carriers; 0/Ions; 0/Malates; 0/Polymers; 0/poly(malic acid); 114-07-8/Erythromycin; 25513-46-6/Polyglutamic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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