| Ion transport in the colon of rats experimentally infected with liver fluke (Fasciola hepatica). | |
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MedLine Citation:
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PMID: 19058567 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effect of liver fluke infection (Fasciola hepatica) on ion transport in the rat proximal colon was evaluated with electrophysiological methods using an Ussing apparatus. Rats were orally infected with F. hepatica metacercariae. The experimental groups of rats at 4 weeks post-infection (wpi) were in the acute stage of fasciolosis, while those at 7, 10 and 13 wpi represented the chronic phase of liver fluke infection. The control group comprised uninfected rats. The experiment consisted of recording transepithelial electrical potential difference (PD) and transepithelial electrical resistance (R) in the colon of the rats. The results revealed reduced PD levels in the colon of rats, especially during the acute phase of fasciolosis. During its chronic phase, a gradual growth in the intestinal transepithelial potential difference was found. Rat fasciolosis did not cause changes in colon sensitivity to mechanical stimulation or in the value of electrical resistance. Only at 13 wpi was resistance found to have dropped. The results have demonstrated that experimental fasciolosis leads to activation of inflammatory mediators and thus to stimulation of nerve fibres, which modifies ion transport in the epithelium of the host large intestine. |
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Authors:
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Danuta Izabela Kosik-Bogacka; Lidia Kołodziejczyk |
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Publication Detail:
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Type: In Vitro; Journal Article |
Journal Detail:
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Title: Folia biologica Volume: 52 ISSN: 0015-5497 ISO Abbreviation: Folia Biol. (Krakow) Publication Date: 2004 |
Date Detail:
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Created Date: 2008-12-08 Completed Date: 2009-01-23 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 2984758R Medline TA: Folia Biol (Krakow) Country: Poland |
Other Details:
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Languages: eng Pagination: 243-6 Citation Subset: IM |
Affiliation:
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Department of Biology and Medical Parasitology, Pomeranian Medical University, Powstańców Wielkopolskich Av. 72, 70-111 Szczecin, Poland. kodan@sci.pam.szczecin.pl |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Colon / metabolism Fasciola hepatica* Fascioliasis / metabolism*, parasitology Intestinal Diseases, Parasitic / metabolism*, parasitology Ion Transport Male Rats Rats, Wistar |
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