Document Detail


Ion-osmotic hyperthermia during exercise in dogs.
MedLine Citation:
PMID:  1251913     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The influence of intravenous infusions of various concentrations of NaCl solutions on temperature regulation was investigated in dogs at rest and during moderate exercise for 1 h on a treadmill. Infusion of hypertonic solutions either before and during exercise resulted in elevated (P less than 0.05) plasma Na+ and osmotic concentrations and produced higher equilibrium levels (P less than 0.05) of rectal temperature (Tre) during exercise (prehypertonic 40.9 degrees C vs. no infusion 40.4 degrees C; hypertonic 40.8 degrees C vs. isotonic infusion 40.4 degrees C), but not at rest. Increasing the [Na+] and osmotic concentrations above 170 meq/liter and 325 mosmol/kg, respectively, resulted in no additional increase in exercise Tre. Water consumption during exercise decreased (P less than 0.05) plasma [Na+], osmolality, and the equilibrium level of Tre to control levels. There was no effect of changes in plasma volume (PV) of +/- 8% on the time course, equilibrium level, or change in Tre during exercise. At the end of exercise, there were moderate correlations (P less than 0.01) between Tre and [Na+] (r = 0.51) and Tre and osmoti (r = 0.52) concentrations. It was concluded that a) the exercise Tre responses of the dog respond quantitatively like man to elevated plasma [Na+] and osmolality, b) the Tre levels are not influenced by changes in PV, and c) water intake significantly reduces the ion-osmotic hyperthermia.
Authors:
J E Greenleaf; S Kolzowski; K Nazar; H Kaciuba-Uściłko; Z Brzezińska; A Ziemba
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The American journal of physiology     Volume:  230     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1976 Jan 
Date Detail:
Created Date:  1976-04-09     Completed Date:  1976-04-09     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  74-9     Citation Subset:  IM; S    
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MeSH Terms
Descriptor/Qualifier:
Animals
Blood Proteins
Body Temperature Regulation / drug effects*
Dogs
Drinking
Hematocrit
Male
Osmolar Concentration
Physical Exertion*
Plasma Volume
Potassium / blood
Sodium / blood
Sodium Chloride / pharmacology*
Chemical
Reg. No./Substance:
0/Blood Proteins; 7440-09-7/Potassium; 7440-23-5/Sodium; 7647-14-5/Sodium Chloride

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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