Document Detail

Ion movements in cell death: from protection to execution.
MedLine Citation:
PMID:  12415738     Owner:  NLM     Status:  MEDLINE    
Cell death is preceded by severe disruption of inorganic ion homeostasis. Seconds to minutes after an injury, calcium, protons, sodium, potassium and chloride are exchanged between the cell and its environment. Simultaneously, ions are shifted between membrane compartments inside the cell, whereby mitochondria and endoplasmic reticulum play a crucial role. Depending of the type and severity of injury, two mutually exclusive metastable states can be reached, which predict the final outcome. Cells characterized by large increases in cytosolic [Ca2+], [Na+] and [Mg2+] swell and die by necrosis; alternatively, cells characterized by high [H+] and low [K+], with normal [Na+] and normal to moderate [Ca2+] increases die by apoptosis. The levels of these ions represent central determinants in signaling events leading to cell death. Their movements are explained mechanistically by specific modulation of membrane transport proteins including channels, pumps and carriers.
Luis Felipe Barros; Joel Castro; Carla X Bittner
Related Documents :
3183978 - Relations between cell volume control, microfilaments and microtubules networks in t2 a...
12898258 - Recovery of cell volume and electrolytes of a6 cells after re-establishing isotonicity ...
14962318 - Analysis of maternal and neonatal factors that influence the nucleated and cd34+ cell y...
6396378 - A miniature flow cell designed for rapid exchange of media under high-power microscope ...
16609888 - Aristolochic acid i-induced dna damage and cell cycle arrest in renal tubular epithelia...
22674118 - Studying the non-thermal effects of terahertz radiation on e. coli/pkatg-gfp biosensor ...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Biological research     Volume:  35     ISSN:  0716-9760     ISO Abbreviation:  Biol. Res.     Publication Date:  2002  
Date Detail:
Created Date:  2002-11-05     Completed Date:  2003-02-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9308271     Medline TA:  Biol Res     Country:  Chile    
Other Details:
Languages:  eng     Pagination:  209-14     Citation Subset:  IM    
Centro de Estudios Científicos CECS, Arturo Prat 514, Casilla 1469, Valdivia, Chile.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Calcium / metabolism
Cell Death / physiology*
Ion Channels / metabolism*,  physiology
Ion Transport
Magnesium / metabolism
Potassium / metabolism
Proto-Oncogene Proteins c-bcl-2 / metabolism
Sodium / metabolism
Reg. No./Substance:
0/Ion Channels; 0/Proto-Oncogene Proteins c-bcl-2; 7439-95-4/Magnesium; 7440-09-7/Potassium; 7440-23-5/Sodium; 7440-70-2/Calcium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Molecular interplay between ion channels and the regulation of apoptosis.
Next Document:  Non-selective cation channels and oxidative stress-induced cell swelling.