Document Detail


Ion movements in cell death: from protection to execution.
MedLine Citation:
PMID:  12415738     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Cell death is preceded by severe disruption of inorganic ion homeostasis. Seconds to minutes after an injury, calcium, protons, sodium, potassium and chloride are exchanged between the cell and its environment. Simultaneously, ions are shifted between membrane compartments inside the cell, whereby mitochondria and endoplasmic reticulum play a crucial role. Depending of the type and severity of injury, two mutually exclusive metastable states can be reached, which predict the final outcome. Cells characterized by large increases in cytosolic [Ca2+], [Na+] and [Mg2+] swell and die by necrosis; alternatively, cells characterized by high [H+] and low [K+], with normal [Na+] and normal to moderate [Ca2+] increases die by apoptosis. The levels of these ions represent central determinants in signaling events leading to cell death. Their movements are explained mechanistically by specific modulation of membrane transport proteins including channels, pumps and carriers.
Authors:
Luis Felipe Barros; Joel Castro; Carla X Bittner
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Biological research     Volume:  35     ISSN:  0716-9760     ISO Abbreviation:  Biol. Res.     Publication Date:  2002  
Date Detail:
Created Date:  2002-11-05     Completed Date:  2003-02-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9308271     Medline TA:  Biol Res     Country:  Chile    
Other Details:
Languages:  eng     Pagination:  209-14     Citation Subset:  IM    
Affiliation:
Centro de Estudios Científicos CECS, Arturo Prat 514, Casilla 1469, Valdivia, Chile. fbarros@cecs.cl
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MeSH Terms
Descriptor/Qualifier:
Animals
Calcium / metabolism
Cell Death / physiology*
Humans
Ion Channels / metabolism*,  physiology
Ion Transport
Magnesium / metabolism
Potassium / metabolism
Proto-Oncogene Proteins c-bcl-2 / metabolism
Sodium / metabolism
Chemical
Reg. No./Substance:
0/Ion Channels; 0/Proto-Oncogene Proteins c-bcl-2; 7439-95-4/Magnesium; 7440-09-7/Potassium; 7440-23-5/Sodium; 7440-70-2/Calcium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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