Document Detail


Ion fluxes, transmembrane potential, and osmotic stabilization: a new dynamic electrophysiological model for eukaryotic cells.
MedLine Citation:
PMID:  21079946     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Survival of mammalian cells is achieved by tight control of cell volume, while transmembrane potential has been known to control many cellular functions since the seminal work of Hodgkin and Huxley. Regulation of cell volume and transmembrane potential have a wide range of implications in physiology, from neurological and cardiac disorders to cancer and muscle fatigue. Therefore, understanding the relationship between transmembrane potential, ion fluxes, and cell volume regulation has become of great interest. In this paper we derive a system of differential equations that links transmembrane potential, ionic concentrations, and cell volume. In particular, we describe the dynamics of the cell within a few seconds after an osmotic stress, which cannot be done by the previous models in which either cell volume was constant or osmotic regulation instantaneous. This new model demonstrates that both membrane potential and cell volume stabilization occur within tens of seconds of changes in extracellular osmotic pressure. When the extracellular osmotic pressure is constant, the cell volume varies as a function of transmembrane potential and ion fluxes, thus providing an implicit link between transmembrane potential and cell volume. Experimental data provide results that corroborate the numerical simulations of the model in terms of time-related changes in cell volume and dynamics of the phenomena. This paper can be seen as a generalization of previous electrophysiological results, since under restrictive conditions they can be derived from our model.
Authors:
Clair Poignard; Aude Silve; Frederic Campion; Lluis M Mir; Olivier Saut; Laurent Schwartz
Related Documents :
19615336 - Ciia induces the epithelial-mesenchymal transition and cell invasion.
21481036 - Cell therapy for ischaemic stroke.
11834096 - Immunohistochemical analysis of cd1a-labeled langerhans cells in human dental periapica...
10803426 - Lens uva photobiology.
12625716 - A chemical surface modification of chitosan by glycoconjugates to enhance the cell-biom...
21573686 - β-carotene production by saccharomyces cerevisiae with regard to plasmid stability and...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2010-11-16
Journal Detail:
Title:  European biophysics journal : EBJ     Volume:  -     ISSN:  1432-1017     ISO Abbreviation:  Eur. Biophys. J.     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-11-16     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8409413     Medline TA:  Eur Biophys J     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
INRIA Bordeaux-Sud Ouest Team research MC2, Institut Mathématiques de Bordeaux, UMR CNRS 5251 (Applied Mathematics), 351, cours de la Libération, 33405, Talence Cedex, France, clair.poignard@inria.fr.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Neuroblastoma with primary pleural involvement: an unusual presentation.
Next Document:  Redox regulation of morphology, cell stiffness, and lectin-induced aggregation of human platelets.