| Ion channels, transporters, and pumps as targets for heart failure therapy. | |
| | |
MedLine Citation:
|
PMID: 19365280 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Congestive heart failure is a leading cause of morbidity and mortality. Congestive heart failure is marked by atrial and ventricular enlargements and reduced cardiac contractility and an association with an increased incidence of atrial and ventricular arrhythmias and sudden cardiac death. Dysfunctional ion channel function is one of the major underlying mechanisms of the reduced contractility and arrhythmias. In this review, we explore the utility of ion channels, transporters, and pumps as targets for the treatment of heart failure, focusing predominantly on the treatment for reduced contractility and arrhythmias. |
| | |
Authors:
|
Darshan Doshi; Steven O Marx |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
|
Title: Journal of cardiovascular pharmacology Volume: 54 ISSN: 1533-4023 ISO Abbreviation: J. Cardiovasc. Pharmacol. Publication Date: 2009 Oct |
Date Detail:
|
Created Date: 2009-10-23 Completed Date: 2010-03-25 Revised Date: 2011-09-26 |
Medline Journal Info:
|
Nlm Unique ID: 7902492 Medline TA: J Cardiovasc Pharmacol Country: United States |
Other Details:
|
Languages: eng Pagination: 273-8 Citation Subset: IM |
Affiliation:
|
Division of Cardiology, Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Arrhythmias, Cardiac / complications, drug therapy, metabolism, physiopathology Heart Failure / complications, drug therapy*, metabolism, physiopathology Humans Ion Channel Gating / drug effects Ion Channels / metabolism* Myocardial Contraction / drug effects |
| Grant Support | |
ID/Acronym/Agency:
|
R01 HL068093-06/HL/NHLBI NIH HHS; R01 HL68093/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Ion Channels |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Differences among low-molecular-weight heparins: evidence in patients with acute coronary syndromes.
Next Document: Optimization of hypertension management: the role of Angiotensin receptor blocker-calcium channel bl...