Document Detail

Ion-channels on parasite muscle: pharmacology and physiology.
MedLine Citation:
PMID:  17999098     Owner:  NLM     Status:  MEDLINE    
Ion-channels are essential components of excitable cells. This fact has been exploited in the development of anthelmintic agents; the majority of which act on nematode ion channels. The purpose of this review is to describe the site of action of some frequently used anthelmintic compounds: nAChRs and levamisole/pyrantel; Glu-Cls and avermectins/mylbemycins; GABA receptors and piperazine. Also described is some of the physiological and pharmacological data on other nematode muscle ion-channels which may prove attractive targets for future anthelmintic development: Ca2+ activated Cl(-) channels; peptide gated chloride Cl(-) channels; Ca2+ channels and potassium channels. Emphasis is placed on the pharmacological and physiological data from parasite tissue. Information on the genes involved in ion-channel formation and modulation are reviewed in detail elsewhere in this issue.
Alan P Robertson; Richard J Martin
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review     Date:  2007-11-13
Journal Detail:
Title:  Invertebrate neuroscience : IN     Volume:  7     ISSN:  1354-2516     ISO Abbreviation:  Invert. Neurosci.     Publication Date:  2007 Dec 
Date Detail:
Created Date:  2007-11-26     Completed Date:  2008-01-31     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9602489     Medline TA:  Invert Neurosci     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  209-17     Citation Subset:  IM    
Department of Biomedical Sciences, Iowa State University, Ames, IA 50011, USA.
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MeSH Terms
Anthelmintics / pharmacology*
Helminths / drug effects*,  physiology*
Ion Channels / physiology*
Muscles / drug effects,  physiology
Grant Support
Reg. No./Substance:
0/Anthelmintics; 0/Ion Channels

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