Document Detail


Ion channels in membranes.
MedLine Citation:
PMID:  6273012     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The membranes that separate the myocardial cell interior from the extracellular space and delimit compartments within the myocardial cell represent ion-impermeable phospholipid barriers. Embedded in these phospholipid membranes are intrinsic membrane proteins, some of which serve as ion channels. The voltage-sensitive ion channels that control the sarcolemmal action potential appear to be highly regulated intrinsic membrane proteins that contain "gates" that respond to changing membrane potential by opening and closing an ion-selective "pore" that allows specific ions to cross the membrane. Pharmacologic blockade of the sarcolemmal ion channels is selective, not only for individual classes of ion channels, but also for specific states of a given type of channel. The basis for this selectivity remains unclear, but may derive from a preferential interaction between a given drug and a specific type of ion-channel protein, or a selective drug action on a structurally specific region of the membrane phospholipid that is in intimate contact with the ion-channel protein.
Authors:
A M Katz; F C Messineo; L Herbette
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Circulation     Volume:  65     ISSN:  0009-7322     ISO Abbreviation:  Circulation     Publication Date:  1982 Jan 
Date Detail:
Created Date:  1982-02-25     Completed Date:  1982-02-25     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0147763     Medline TA:  Circulation     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  I2-10     Citation Subset:  AIM; IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Biological Transport, Active
Carbohydrates / physiology
Humans
Ion Channels / drug effects,  physiology*
Membrane Lipids / physiology
Membrane Proteins / physiology
Membranes / physiology
Myocardium / metabolism*
Sarcolemma / metabolism
Grant Support
ID/Acronym/Agency:
HL-21812/HL/NHLBI NIH HHS; HL-22135/HL/NHLBI NIH HHS; HL-27630/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Carbohydrates; 0/Ion Channels; 0/Membrane Lipids; 0/Membrane Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Response of the systemic and pulmonary circulation to converting-enzyme inhibition (captopril) at re...
Next Document:  Optimized assay for serum angiotensin-converting enzyme activity.