Document Detail


Ion channels in epilepsy.
MedLine Citation:
PMID:  9476174     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
There are specific alterations in the structure or function of ion channels in the epileptic brain. Some of these alterations may promote hyperexcitability, whereas others may protect neurons from the deleterious effects of epileptic discharges. With the use of human tissue resected from epilepsy patients and the comparison of cellular properties to those found in well-defined experimental models, we will continue to gain insight into the specific ion channel changes associated with epilepsies. Further genetic studies will help to elucidate the altered molecular mechanisms underlying ion channel changes in this devastating neurological disorder (Noebels, 1996). Whether it is a change in structure, function, or both, the study of ion channels in epilepsies will soon reveal specific characteristics of ion channels found only in epileptic tissue. If the altered properties of such ion channels cannot be found in control (nonepileptic) neurons, these channels might be called "epileptic" ion channels. An understanding of the specific structure, function, and pharmacology of these "epileptic" channels will yield important clues for future therapeutical approaches aimed at preventing epileptogenesis, and insight into the processes whereby ion channels become "epileptic" may finally open the way to prophylactic treatments of the epilepsies.
Authors:
I Mody
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  International review of neurobiology     Volume:  42     ISSN:  0074-7742     ISO Abbreviation:  Int. Rev. Neurobiol.     Publication Date:  1998  
Date Detail:
Created Date:  1998-03-19     Completed Date:  1998-03-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0374740     Medline TA:  Int Rev Neurobiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  199-226     Citation Subset:  IM    
Affiliation:
Department of Neurology, Reed Neurological Research Center, University of California-Los Angeles School of Medicine 90095, USA.
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MeSH Terms
Descriptor/Qualifier:
Epilepsy / etiology,  physiopathology*
Gene Expression Regulation / physiology
Humans
Ion Channel Gating
Ion Channels / physiology*
Ligands
Membrane Potentials / physiology
Neurons / physiology*
Receptors, GABA-A / physiology
Chemical
Reg. No./Substance:
0/Ion Channels; 0/Ligands; 0/Receptors, GABA-A

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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