Document Detail

Iohexol and meglumine iothalamate in phlebography of the leg. Comparison of the tolerance.
MedLine Citation:
PMID:  6382936     Owner:  NLM     Status:  MEDLINE    
Fifty patients were examined by ascending phlebography of both legs in a prospective, double blind, within-patient series. Each leg was randomly allocated to the examination using either iohexol 300 mg I/ml or meglumine iothalamate 280 mg I/ml as the contrast medium. Immediate side effects were recorded in all patients, and delayed effects in 45 patients. Statistical analysis using the chi-square test showed that iohexol produced significantly less immediate pain in the leg than meglumine iothalamate. Iohexol produced significantly less nausea, and vomiting during the injection than meglumine iothalamate. No significant difference was found in the incidence of delayed pain and swelling with either medium. The quality of the films produced by iohexol was significantly better than that obtained with meglumine iothalamate.
M Lea Thomas; G M Briggs; F P Keeling
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Acta radiologica. Supplementum     Volume:  366     ISSN:  0365-5954     ISO Abbreviation:  Acta Radiol Suppl     Publication Date:  1983  
Date Detail:
Created Date:  1984-09-27     Completed Date:  1984-09-27     Revised Date:  2008-04-09    
Medline Journal Info:
Nlm Unique ID:  0370370     Medline TA:  Acta Radiol Suppl     Country:  SWEDEN    
Other Details:
Languages:  eng     Pagination:  54-7     Citation Subset:  IM    
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MeSH Terms
Clinical Trials as Topic
Contrast Media / toxicity*
Double-Blind Method
Drug Tolerance
Edema / etiology
Flushing / etiology
Iodobenzoates / toxicity*
Iothalamate Meglumine / diagnostic use,  toxicity*
Leg / blood supply,  radiography*
Middle Aged
Pain / etiology
Random Allocation
Triiodobenzoic Acids / diagnostic use,  toxicity*
Reg. No./Substance:
0/Contrast Media; 0/Iodobenzoates; 0/Triiodobenzoic Acids; 13087-53-1/Iothalamate Meglumine; 66108-95-0/Iohexol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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