Document Detail

Iohexol cerebral angiography. Multicenter clinical trial.
MedLine Citation:
PMID:  3882617     Owner:  NLM     Status:  MEDLINE    
Ionic contrast media currently used in cerebral angiography frequently cause discomfort due to hyperosmolality. This double-blind, multicenter trial compared two ionic media, meglumine iothalamate and meglumine-Na diatrizoate, with the new nonionic agent, iohexol, in 277 patients undergoing cerebral angiography. Vital signs, cardiovascular changes, and neurologic status were evaluated before, during, and after injection. Patients were observed for adverse reactions for up to 24 hours following studies. Patient discomfort and image quality were evaluated. Visualization was good or excellent with all media studied. No significant physiological differences were observed between the ionic and iohexol groups, but fewer iohexol patients experienced large increases (greater than 20 mmHg) in systolic blood pressure. Iohexol patients experienced significantly less discomfort; ionic patients reported severe discomfort 21/2 times more often. This finding was attributed to iohexol's low osmolality. Iohexol may be indicated particularly for use in selective angiograms where discomfort is a factor and for patients suspected of having blood-brain barrier disruption.
D K Kido; D G Potts; R N Bryan; D Norman; D M Pelz; A J Fox; D D Shaw
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Controlled Clinical Trial; Journal Article    
Journal Detail:
Title:  Investigative radiology     Volume:  20     ISSN:  0020-9996     ISO Abbreviation:  Invest Radiol     Publication Date:    1985 Jan-Feb
Date Detail:
Created Date:  1985-04-10     Completed Date:  1985-04-10     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0045377     Medline TA:  Invest Radiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  S55-7     Citation Subset:  IM    
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MeSH Terms
Blood Pressure / drug effects
Blood-Brain Barrier / drug effects
Cerebral Angiography*
Clinical Trials as Topic
Contrast Media* / adverse effects
Diatrizoate Meglumine / adverse effects,  diagnostic use
Double-Blind Method
Headache / chemically induced
Iodobenzoates / diagnostic use*
Iothalamate Meglumine / adverse effects,  diagnostic use
Middle Aged
Nausea / chemically induced
Osmolar Concentration
Triiodobenzoic Acids / adverse effects,  diagnostic use*
Reg. No./Substance:
0/Contrast Media; 0/Iodobenzoates; 0/Triiodobenzoic Acids; 13087-53-1/Iothalamate Meglumine; 131-49-7/Diatrizoate Meglumine; 66108-95-0/Iohexol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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