Document Detail

Iohexol as a marker of glomerular filtration rate in patients with diabetes: comparison of multiple and simplified sampling protocols.
MedLine Citation:
PMID:  11251674     Owner:  NLM     Status:  MEDLINE    
AIMS: To report on the reproducibility of iohexol glomerular filtration rate (GFR) estimation, to compare the plasma clearance of iohexol with that of[51Cr]EDTA and to evaluate the reliability of reduced sampling schedules in estimating GFR in Type 1 and Type 2 diabetes mellitus. METHODS: Agreement was assessed in 15 Type 1 and 26 Type 2 diabetics with creatinine ranging from 53 to 564 micromol/l. RESULTS: The regression between multiple-sample iohexol and[51Cr]EDTA clearances was 0.999 in Type 1 and 0.987 in Type 2 diabetes (P < 0.0001 for both). A seven-sample design and the three-sample approach by Brøchner-Mortensen were validated by comparison with the full-sample schedule in 87 patients (51 Type 1, 36 Type 2). Full-sample GFR was 80.3 +/- 43.8, seven-sample 79.5 +/- 43.9 (r = 0.990) and three-sample 79.8 +/- 45.2 ml.min-1.1.73 m-2 (r = 0.972). The coefficients of variation of GFR were 2.7 +/- 1.4% and 3.8 +/- 1.9% for the full-sample and the seven-sample approaches, respectively, and significantly higher for the three-sample design (6.9 +/- 3.4%, P = 0.0001). CONCLUSIONS: After iohexol injection, the Brøchner-Mortensen schedule does not provide an accurate estimate of GFR. The seven-sample approach gives acceptable errors and allows a good estimate of GFR throughout a wide range of renal function.
L Pucci; S Bandinelli; M Pilo; M Nannipieri; R Navalesi; G Penno
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Diabetic medicine : a journal of the British Diabetic Association     Volume:  18     ISSN:  0742-3071     ISO Abbreviation:  Diabet. Med.     Publication Date:  2001 Feb 
Date Detail:
Created Date:  2001-03-19     Completed Date:  2001-05-03     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8500858     Medline TA:  Diabet Med     Country:  England    
Other Details:
Languages:  eng     Pagination:  116-20     Citation Subset:  IM    
Department of Endocrinology and Metabolism, University of Pisa, and Cisanello Hospital of Pisa Azienda Ospedaliera Pisana, Pisa, Italy.
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MeSH Terms
Analysis of Variance
Chromium Radioisotopes / diagnostic use,  pharmacokinetics
Contrast Media
Diabetes Mellitus, Type 1 / physiopathology*
Diabetes Mellitus, Type 2 / physiopathology*
Edetic Acid / diagnostic use,  pharmacokinetics
Glomerular Filtration Rate*
Hemoglobin A, Glycosylated / analysis
Iohexol / diagnostic use,  pharmacokinetics*
Metabolic Clearance Rate
Middle Aged
Models, Biological
Regression Analysis
Reproducibility of Results
Reg. No./Substance:
0/Chromium Radioisotopes; 0/Contrast Media; 0/Hemoglobin A, Glycosylated; 60-00-4/Edetic Acid; 66108-95-0/Iohexol

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