| Iodothyronamines are oxidatively deaminated to iodothyroacetic acids in vivo. | |
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MedLine Citation:
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PMID: 19105176 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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3-Iodothyronamine (T(1)AM) and 3,3',5-triiodothyroacetic acid (Triac) are bioactive metabolites of the hormone thyroxine (T(4)). In the present study, the ability of T(1)AM and 3,3',5-triiodothyronamine (T(3)AM) to be metabolized to 3-iodothyroacetic acid (TA(1)) and Triac, respectively, was investigated. Both T(1)AM and T(3)AM were converted to their respective iodinated thyroacetic acid analogues in both cell and tissue extracts. This conversion could be significantly inhibited with the monamine oxidase (MAO) and semicarbazide-sensitive amine oxidase (SSAO) inhibitor iproniazid. TA(1) was found to be present in trace quantities in human serum and in substantial levels in serum from T(1)AM-treated rats. These results demonstrate that iodothyronamines are substrates for amine oxidases and that this metabolism may be the source of the corresponding endogenous arylacetic acid products Triac and TA(1). |
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Authors:
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Warren J L Wood; Travis Geraci; Aaron Nilsen; Andrea E DeBarber; Thomas S Scanlan |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural |
Journal Detail:
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Title: Chembiochem : a European journal of chemical biology Volume: 10 ISSN: 1439-7633 ISO Abbreviation: Chembiochem Publication Date: 2009 Jan |
Date Detail:
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Created Date: 2009-01-21 Completed Date: 2009-03-05 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100937360 Medline TA: Chembiochem Country: Germany |
Other Details:
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Languages: eng Pagination: 361-5 Citation Subset: IM |
Affiliation:
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Department of Physiology and Pharmacology, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Mail Code L334, Portland, OR 97239, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aldehyde Dehydrogenase
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metabolism Animals Deamination Humans Monoamine Oxidase / metabolism Oxidation-Reduction Rats Substrate Specificity Thyronines / chemistry, metabolism* Triiodothyronine / analogs & derivatives*, chemistry, metabolism |
| Grant Support | |
ID/Acronym/Agency:
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DK-077402/DK/NIDDK NIH HHS; DK-52798/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/3-iodothyronamine; 0/Thyronines; 51-24-1/3,3',5-triiodothyroacetic acid; 6893-02-3/Triiodothyronine; EC 1.2.1.3/Aldehyde Dehydrogenase; EC 1.4.3.4/Monoamine Oxidase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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