Document Detail

Iodopovidone is as effective as doxycycline in producing pleurodesis in rabbits.
MedLine Citation:
PMID:  20199636     Owner:  NLM     Status:  MEDLINE    
BACKGROUND AND OBJECTIVE: The mechanism by which iodopovidone achieves pleurodesis is unknown. This study investigated whether iodopovidone is as effective as doxycycline in producing pleurodesis and whether systemic corticosteroids diminish its efficacy. METHODS: Four groups of seven New Zealand rabbits were assigned to the following intrapleural treatment groups: 2 mL of 2% iodopovidone, 2 mL of 4% iodopovidone, 2 mL of 4% iodopovidone plus 0.8 mg/kg triamcinolone intramuscularly weekly and 10 mL/kg doxycycline in 2 mL. Pleural fluid was collected 24, 48 and 72 h after intrapleural injections and analysed for WCC, protein and LDH levels. The rabbits were killed 2 weeks after the injections. Pleurodesis was graded macroscopically on a scale from 1 to 8. The degree of microscopic pleural fibrosis and pleural inflammation was graded from the HE stain slides. RESULTS: The mean volume of pleural fluid as well as the mean total WCC was significantly lower in the steroid-treated group than in the other groups. The degree of the resulting pleurodesis was similar in the 2% iodopovidone (7.00 +/- 1.29), 4% iodopovidone (7.71 +/- 0.76) and doxycycline (7.14 +/- 0.90) groups (P > 0.05) whereas the pleurodesis score of the steroid group (3.71 +/- 1.98) was significantly lower than all other groups (P < 0.05). The degree of microscopic pleural fibrosis and pleural inflammation was significantly lower in the steroid group than in the 2% iodopovidone or 4% iodopovidone group. CONCLUSIONS: Both 2% and 4% iodopovidone can induce pleurodesis as efficaciously as doxycycline in rabbits. Systemic corticosteroids significantly decrease the efficacy of iodopovidone in producing pleurodesis.
Yubiao Guo; Kejing Tang; Semra Bilaceroglu; Ioannis Kalomenidis; Kenneth J Salleng; Kirk B Lane; Richard W Light
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Respirology (Carlton, Vic.)     Volume:  15     ISSN:  1440-1843     ISO Abbreviation:  Respirology     Publication Date:  2010 Jan 
Date Detail:
Created Date:  2010-03-04     Completed Date:  2010-06-18     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9616368     Medline TA:  Respirology     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  119-25     Citation Subset:  IM    
Department of Pulmonary and Critical Care Medicine, the First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, China.
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MeSH Terms
Doxycycline / administration & dosage*
Inflammation / chemically induced
L-Lactate Dehydrogenase / analysis
Leukocyte Count
Pleura / drug effects
Pleurodesis / methods*
Povidone-Iodine / administration & dosage*
Triamcinolone / administration & dosage
Reg. No./Substance:
124-94-7/Triamcinolone; 25655-41-8/Povidone-Iodine; 564-25-0/Doxycycline; EC Dehydrogenase
Comment In:
Respirology. 2010 Jan;15(1):4-5   [PMID:  20199631 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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