| Iodoethylspiperone, a new potential agent for exploration of central dopamine D2 receptors: synthesis and preliminary in vivo study. | |
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MedLine Citation:
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PMID: 2143754 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We synthesized a new spiperone derivative: iodoethylspiperone (IES) to perform dopamine D2 receptor exploration by SPECT. IES was prepared from a precursor: tosylethylspiperone, and characterized by i.r. and 1H-NMR analyses. [125I]IES was obtained with 80% yield. In vivo biodistribution in rats showed a high and specific uptake in the striatum. The uptake ratio between the striatum and the cerebellum reached a maximum value 4 h after injection (10.05 +/- 2.81). IES labeled with 123I should be a promising new agent to investigate D2 receptors in the living human brain. |
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Authors:
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S Chalon; Y Frangin; D Guilloteau; M Caillet; C Guimbal; M H Schmitt; G Desplanches; J L Baulieu; J C Besnard |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology Volume: 17 ISSN: 0883-2897 ISO Abbreviation: Int J Rad Appl Instrum B Publication Date: 1990 |
Date Detail:
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Created Date: 1990-09-27 Completed Date: 1990-09-27 Revised Date: 2008-02-21 |
Medline Journal Info:
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Nlm Unique ID: 8611098 Medline TA: Int J Rad Appl Instrum B Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 389-95 Citation Subset: IM |
Affiliation:
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INSERM U316, Laboratoire de Biophysique Médicale, Tours, France. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Brain / metabolism*, radionuclide imaging Cerebellum / metabolism, radionuclide imaging Corpus Striatum / metabolism, radionuclide imaging Iodine Radioisotopes / diagnostic use Male Rats Rats, Inbred Strains Receptors, Dopamine* Receptors, Dopamine D2 Spiperone / analogs & derivatives*, chemical synthesis, pharmacokinetics Tomography, Emission-Computed |
| Chemical | |
Reg. No./Substance:
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0/Iodine Radioisotopes; 0/Receptors, Dopamine; 0/Receptors, Dopamine D2; 130482-21-2/iodoethylspiperone; 749-02-0/Spiperone |
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