Document Detail

Iodine insufficiency and neonatal hyperthyrotropinaemia in Hong Kong.
MedLine Citation:
PMID:  9156041     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: 23% of the neonatal hypothyroidism in Hong Kong is transient. The present study aims to evaluate iodine excretion in healthy pregnant women in Hong Kong and to determine whether iodine insufficiency may occur in the local population to account for the type of neonatal thyroid dysfunction seen in our screening programme. SUBJECTS: Pilot screening of urinary iodine excretion was determined in 253 healthy pregnant women between 32 and 36 weeks gestation. Fetal and maternal thyroid function in relation to urinary iodine excretion was evaluated in another 55 pregnant women who had given birth to infants with cord blood TSH > or = 16 mIU/I (95th percentile of the cord blood TSH screening programme) and the results were compared to a control group of 160 healthy women whose infants had cord blood TSH < 16 mIU/I. RESULTS: Using a cut-off value of 0.79 mumol/l, a level as defined by WHO as iodine deficiency, we found that 35.8% of the pregnant women had urinary iodine concentrations below this cut off value. We demonstrated that the existence of borderline iodine supply affected the maternal and fetal thyroid function as evidenced by (i) a negative correlation between maternal TSH and urinary iodine concentration, (ii) higher cord blood TSH in those infants whose mothers had a low urinary iodine concentration as compared to those in whose mothers it was normal, (iii) women who had given birth to infants with cord blood TSH > or = 16 mIU/I had lower urinary iodine concentrations and serum fT4 levels as compared to mothers who had given birth to infants with normal cord TSH levels, and their offspring also had higher cord blood thyroglobulin levels. CONCLUSION: Although Hong Kong is not a goitrous area, borderline iodine deficiency exists. Iodization of salt in our community could obviate the necessity for iodine supplements in pregnant women and other at-risk groups.
A W Kung; T T Lao; L C Low; R W Pang; J D Robinson
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical endocrinology     Volume:  46     ISSN:  0300-0664     ISO Abbreviation:  Clin. Endocrinol. (Oxf)     Publication Date:  1997 Mar 
Date Detail:
Created Date:  1997-06-05     Completed Date:  1997-06-05     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0346653     Medline TA:  Clin Endocrinol (Oxf)     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  315-9     Citation Subset:  IM    
Department of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong.
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MeSH Terms
Congenital Hypothyroidism*
Fetal Blood / chemistry
Hong Kong
Hypothyroidism / blood
Infant, Newborn
Iodine / deficiency*,  urine
Postpartum Period
Pregnancy Trimester, Third
Thyrotropin / blood*
Thyroxine / blood
Reg. No./Substance:
7488-70-2/Thyroxine; 7553-56-2/Iodine; 9002-71-5/Thyrotropin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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