| Iodine and hypothyroidism in neonates with congenital heart disease. | |
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MedLine Citation:
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PMID: 9462198 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIM: To evaluate the influence of the intravenous injection of iodine during cardiac catheterisation, and of topical iodine antiseptics during surgical procedures, on thyroid function in full term neonates. METHODS: Twenty one full term infants with major cardiac anomalies who survived for more than a month were studied. Thyroxine and thyrotropin concentrations were measured (by radioimmunoassay) before each procedure, 24 hours after the procedure, and every week thereafter until the age of 1 month or until normal. Thyroxine values less than 64.4 nmol/l were considered low, while thyrotropin values greater than 30 mU/l were considered high. RESULTS: Thyroid function tests before iodine exposure were within normal limits in all infants. Following catheterisation or surgery six infants had raised thyrotropin concentrations; three had low thyroxine concentrations. Two of those infants were treated with L-thyroxine. CONCLUSION: Iodine exposure during cardiac catheterisation or surgery may induce transient hypothyroidism in term infants. |
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Authors:
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N Linder; B Sela; B German; N Davidovitch; J Kuint; J Hegesh; D Lubin; J Sack |
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Publication Detail:
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Type: Clinical Trial; Journal Article |
Journal Detail:
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Title: Archives of disease in childhood. Fetal and neonatal edition Volume: 77 ISSN: 1359-2998 ISO Abbreviation: Arch. Dis. Child. Fetal Neonatal Ed. Publication Date: 1997 Nov |
Date Detail:
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Created Date: 1998-02-19 Completed Date: 1998-02-19 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 9501297 Medline TA: Arch Dis Child Fetal Neonatal Ed Country: ENGLAND |
Other Details:
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Languages: eng Pagination: F239-40 Citation Subset: AIM; IM |
Affiliation:
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Department of Neonatology, Sheba Medical Center, Sackler School of Medicine, Tel Aviv University, Israel. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Anti-Infective Agents, Local
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adverse effects Contrast Media / adverse effects Heart Catheterization Heart Defects, Congenital / therapy* Humans Hypothyroidism / blood, chemically induced* Infant, Newborn Iodine / administration & dosage, adverse effects* Povidone-Iodine / adverse effects Prospective Studies Thyrotropin / blood Thyroxine / blood Triiodobenzoic Acids / adverse effects |
| Chemical | |
Reg. No./Substance:
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0/Anti-Infective Agents, Local; 0/Contrast Media; 0/Triiodobenzoic Acids; 25655-41-8/Povidone-Iodine; 7488-70-2/Thyroxine; 7553-56-2/Iodine; 87771-40-2/ioversol; 9002-71-5/Thyrotropin |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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