Document Detail

Iodine and hypothyroidism in neonates with congenital heart disease.
MedLine Citation:
PMID:  9462198     Owner:  NLM     Status:  MEDLINE    
AIM: To evaluate the influence of the intravenous injection of iodine during cardiac catheterisation, and of topical iodine antiseptics during surgical procedures, on thyroid function in full term neonates. METHODS: Twenty one full term infants with major cardiac anomalies who survived for more than a month were studied. Thyroxine and thyrotropin concentrations were measured (by radioimmunoassay) before each procedure, 24 hours after the procedure, and every week thereafter until the age of 1 month or until normal. Thyroxine values less than 64.4 nmol/l were considered low, while thyrotropin values greater than 30 mU/l were considered high. RESULTS: Thyroid function tests before iodine exposure were within normal limits in all infants. Following catheterisation or surgery six infants had raised thyrotropin concentrations; three had low thyroxine concentrations. Two of those infants were treated with L-thyroxine. CONCLUSION: Iodine exposure during cardiac catheterisation or surgery may induce transient hypothyroidism in term infants.
N Linder; B Sela; B German; N Davidovitch; J Kuint; J Hegesh; D Lubin; J Sack
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Archives of disease in childhood. Fetal and neonatal edition     Volume:  77     ISSN:  1359-2998     ISO Abbreviation:  Arch. Dis. Child. Fetal Neonatal Ed.     Publication Date:  1997 Nov 
Date Detail:
Created Date:  1998-02-19     Completed Date:  1998-02-19     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  9501297     Medline TA:  Arch Dis Child Fetal Neonatal Ed     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  F239-40     Citation Subset:  AIM; IM    
Department of Neonatology, Sheba Medical Center, Sackler School of Medicine, Tel Aviv University, Israel.
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MeSH Terms
Anti-Infective Agents, Local / adverse effects
Contrast Media / adverse effects
Heart Catheterization
Heart Defects, Congenital / therapy*
Hypothyroidism / blood,  chemically induced*
Infant, Newborn
Iodine / administration & dosage,  adverse effects*
Povidone-Iodine / adverse effects
Prospective Studies
Thyrotropin / blood
Thyroxine / blood
Triiodobenzoic Acids / adverse effects
Reg. No./Substance:
0/Anti-Infective Agents, Local; 0/Contrast Media; 0/Triiodobenzoic Acids; 25655-41-8/Povidone-Iodine; 7488-70-2/Thyroxine; 7553-56-2/Iodine; 87771-40-2/ioversol; 9002-71-5/Thyrotropin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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