Document Detail


Iodine deficiency in northern Paris area: impact on fetal thyroid mensuration.
MedLine Citation:
PMID:  21359193     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
INTRODUCTION: Iodine is essential for normal fetal and neonatal development. We studied the prevalence and impact on fetal thyroid development of iodine deficiency in pregnant women in the northern part of the Paris conurbation.
MATERIALS AND METHODS: 110 patients underwent several determinations of urinary iodine excretion (UIE) and of serum FT4, FT3, and TSH. Fetal thyroid gland size was assessed using ultrasonography.
RESULTS: We found evidence of widespread iodine deficiency (mean UIE, 49.8 µg/L [standard deviation, 2.11]). Iodine deficiency did not correlate significantly with maternal thyroid parameters but showed a significant negative correlation with fetal thyroid gland size (rho = 0.25, P = 0.02).
CONCLUSION: Iodine deficiency during pregnancy is still a problem in our geographical area and affects the fetal thyroid gland. Clinical Trials.gov NCT00162539.
Authors:
Dominique Luton; Corinne Alberti; Edith Vuillard; Guillaume Ducarme; Jean François Oury; Jean Guibourdenche
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Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't     Date:  2011-02-16
Journal Detail:
Title:  PloS one     Volume:  6     ISSN:  1932-6203     ISO Abbreviation:  PLoS ONE     Publication Date:  2011  
Date Detail:
Created Date:  2011-03-01     Completed Date:  2011-09-01     Revised Date:  2013-06-30    
Medline Journal Info:
Nlm Unique ID:  101285081     Medline TA:  PLoS One     Country:  United States    
Other Details:
Languages:  eng     Pagination:  e14707     Citation Subset:  IM    
Affiliation:
Université Paris VII, AP-HP, GHU Nord, Hôpital Beaujon, Service de Gynécologie Obstétrique, Clichy, France. dluton@free.fr
Data Bank Information
Bank Name/Acc. No.:
ClinicalTrials.gov/NCT00162539
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MeSH Terms
Descriptor/Qualifier:
Algorithms
Female
Fetus / anatomy & histology
Gestational Age
Humans
Iodine / deficiency*,  therapeutic use
Organ Size
Paris / epidemiology
Pregnancy
Pregnancy Complications / blood,  drug therapy,  etiology*,  urine
Thyroid Diseases / blood,  drug therapy,  etiology*,  urine
Thyroid Function Tests
Thyroid Gland / anatomy & histology,  embryology*,  ultrasonography
Ultrasonography, Prenatal
Chemical
Reg. No./Substance:
7553-56-2/Iodine
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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