| Iodine deficiency as a cause of brain damage. | |
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MedLine Citation:
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PMID: 11264481 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This editorial reviews the impact of iodine deficiency (1) on thyroid function in pregnant women and neonates and (2) on the neurointellectual development of infants and children. All degrees of iodine deficiency (mild: iodine intake of 50-99 microg/day, moderate: 20-49 microg/day, and severe: <20 microg/day) affect thyroid function of the mother and the neonate as well as the mental development of the child. The damage increases with the degree of the deficiency, with overt endemic cretinism as the severest consequence. Maternal hypothyroxinaemia during early pregnancy is a key factor in the development of the neurological damage in the cretin. Selenium deficiency combined with iodine deficiency partly prevents the neurological damage but precipitates severe hypothyroidism in cretins. Iodine deficiency results in a global loss of 10-15 IQ points at a population level and constitutes the world's greatest single cause of preventable brain damage and mental retardation. |
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Authors:
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F Delange |
Publication Detail:
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Type: Editorial; Review |
Journal Detail:
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Title: Postgraduate medical journal Volume: 77 ISSN: 0032-5473 ISO Abbreviation: Postgrad Med J Publication Date: 2001 Apr |
Date Detail:
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Created Date: 2001-03-26 Completed Date: 2001-05-31 Revised Date: 2009-11-03 |
Medline Journal Info:
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Nlm Unique ID: 0234135 Medline TA: Postgrad Med J Country: England |
Other Details:
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Languages: eng Pagination: 217-20 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Brain Damage, Chronic
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embryology,
etiology* Female Humans Infant, Newborn Iodine / deficiency* Mental Retardation / etiology Pregnancy Pregnancy Complications / physiopathology Thyroid Gland / physiopathology Thyroxine / blood |
| Chemical | |
Reg. No./Substance:
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7488-70-2/Thyroxine; 7553-56-2/Iodine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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