Document Detail

Iodine-based radiographic contrast medium may precipitate metformin-associated lactic acidosis in diabetic patients. A case report, literature review and practical approach.
MedLine Citation:
PMID:  22362235     Owner:  NLM     Status:  In-Data-Review    
Lactic acidosis in diabetic patients undergoing metformin therapy is a widely recognized, rare but usually serious adverse event, particularly in presence of comorbidities such as cardiorespiratory disease, sepsis and renal failure. As demonstrated by the case of an elderly woman presented, administration of radiographic iodine-based contrast agents may precipitate lactic acidosis through worsening of renal function. Awareness of this condition, identification of at-risk patients, adequate prevention following published guidelines, early diagnosis and treatment including hemodialysis are necessary to avoid a fatal outcome. Clin Ter 2012; 163(1):59-62.
M Tonolini
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  La Clinica terapeutica     Volume:  163     ISSN:  1972-6007     ISO Abbreviation:  Clin Ter     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-02-24     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372604     Medline TA:  Clin Ter     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  59-62     Citation Subset:  IM    
Radiology Department,Luigi Sacco Hospital, Milan, Italy.
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