| Iodine-131 ablation therapy for a patient receiving peritoneal dialysis. | |
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MedLine Citation:
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PMID: 11290888 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The authors describe a patient with follicular thyroid carcinoma who was receiving continuous ambulatory peritoneal dialysis to manage end-stage renal disease. To deliver radioiodine therapy to ablate thyroid remnants safely and under optimal conditions, the behavior of 37 MBq (1 mCi) I-131 was followed daily for 3 days. Blood activity and total body count decreased with a half-life of 100 hours (4.17 days). The daily iodide removal rate, estimated as a percentage of the total administrated activity, was low: 5.3% to 8.6% in peritoneal dialysate and 1.3% to 2.2% in urine. The thyroid uptake, measured using a probe, was 2.4% to 2.1% from day 1 to day 3 and 1.9% later at day 8. The volume of thyroid remnants was determined by ultrasonography to be 0.6 g. The patient received a reduced ablative I-131 dose of 814 MBq (22 mCi). Radiation emitted from the patient after I-131 therapy, monitored using a radiation monitor probe located at a distance of 1 meter, decreased with an effective half-life of 70 hours (2.9 days). The integration of the curve from t = 0 showed a level always less than 25 microSv/hour as early as 24 hours after treatment. Because the iodine removal rate is continuous but low in a case of peritoneal dialysis, smaller therapeutic doses must be administered to deliver maximal radiation to residual thyroid tissue while minimizing excessive radiation exposure to patients, their families, and medical staff. |
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Authors:
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M E Toubert; C Michel; F Metivier; M C Peker; J D Rain |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Clinical nuclear medicine Volume: 26 ISSN: 0363-9762 ISO Abbreviation: Clin Nucl Med Publication Date: 2001 Apr |
Date Detail:
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Created Date: 2001-04-24 Completed Date: 2001-09-13 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 7611109 Medline TA: Clin Nucl Med Country: United States |
Other Details:
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Languages: eng Pagination: 302-5 Citation Subset: IM |
Affiliation:
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Department of Nuclear Medicine, H pital Saint-Louis, Paris, France. marie-elisabeth.toubert@sls.ap-hop-paris.fr |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Carcinoma, Papillary, Follicular
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complications,
radiotherapy* Half-Life Humans Iodine Radioisotopes / therapeutic use* Male Middle Aged Peritoneal Dialysis, Continuous Ambulatory* Polycystic Kidney Diseases / complications, therapy* Radiometry Thyroid Neoplasms / complications, radiotherapy* |
| Chemical | |
Reg. No./Substance:
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0/Iodine Radioisotopes |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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