| Iodine-131 MIBG uptake in metastatic medullary carcinoma of the thyroid. A patient treated with somatostatin. | |
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MedLine Citation:
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PMID: 2897264 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A 47-year-old man with multiple endocrine neoplasia (MEN) type 2a syndrome in whom metaiodobenzylguanidine (MIBG) concentrated in lesions from metastatic medullary carcinoma of the thyroid is reported. A somatostatin analogue (Sandostatin SMS 201-995) alleviated the symptoms of flushing and diarrhea associated with the elevated calcitonin levels but it did not alter either the course of the disease or the MIBG images. A review of the literature is presented of the noncatecholamine secreting tumors associated with MIBG uptake. Similarities between this case and metastatic carcinoid syndrome are discussed. |
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Authors:
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C A Keeling; L V Basso |
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Publication Detail:
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Type: Case Reports; Journal Article; Review |
Journal Detail:
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Title: Clinical nuclear medicine Volume: 13 ISSN: 0363-9762 ISO Abbreviation: Clin Nucl Med Publication Date: 1988 Apr |
Date Detail:
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Created Date: 1988-06-24 Completed Date: 1988-06-24 Revised Date: 2005-11-16 |
Medline Journal Info:
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Nlm Unique ID: 7611109 Medline TA: Clin Nucl Med Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 260-3 Citation Subset: IM |
Affiliation:
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Department of Diagnostic Radiology, Stanford University School of Medicine, California 94305. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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3-Iodobenzylguanidine Antineoplastic Agents / therapeutic use Carcinoma / metabolism, radionuclide imaging, secondary* Humans Iodine Radioisotopes / diagnostic use* Iodobenzenes / diagnostic use*, pharmacokinetics Male Middle Aged Multiple Endocrine Neoplasia / drug therapy, metabolism, radionuclide imaging* Octreotide Somatostatin / analogs & derivatives*, therapeutic use Spinal Neoplasms / metabolism, radionuclide imaging, secondary* Thyroid Neoplasms / metabolism, radionuclide imaging* |
| Chemical | |
Reg. No./Substance:
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0/Antineoplastic Agents; 0/Iodine Radioisotopes; 0/Iodobenzenes; 51110-01-1/Somatostatin; 77679-27-7/3-Iodobenzylguanidine; 83150-76-9/Octreotide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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